718615-71-5Relevant academic research and scientific papers
Nitrenium ion azaspirocyclization-spirodienone cleavage: A new synthetic strategy for the stereocontrolled preparation of highly substituted lactams and N-hydroxy lactams
Wardrop, Duncan J.,Burge, Matthew S.
, p. 10271 - 10284 (2007/10/03)
Although 1,4-cyclohexadienes 2, obtained through the Birch reduction of arenes 1, have found widespread use as masked β-oxo carbonyl synthons 3, the possibility that 2,5-cyclohexadienones 5 might also be employed to the same end has been overlooked despit
Total synthesis of (-)-dysibetaine via a nitrenium ion cyclization-dienone cleavage strategy
Wardrop, Duncan J.,Burge, Matthew S.
, p. 1230 - 1231 (2007/10/03)
The diastereoselective total synthesis of the marine natural product (-)-dysibetaine is reported. The key steps in this venture are i) a diastereoselective nitrenium ion spirocyclization, which serves to generate the pyrrolidinone ring and quaternary ster
