718629-05-1Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of air-stable nafuredin-γ analogs as complex i inhibitors
Ohtawa, Masaki,Matsunaga, Mari,Fukunaga, Keiko,Shimizu, Risa,Shimizu, Eri,Arima, Shiho,Ohmori, Junko,Kita, Kiyoshi,Shiomi, Kazuro,Omura, Satoshi,Nagamitsu, Tohru
, p. 932 - 943 (2015)
Nafuredin-γ (2), converted from nafuredin (1) under mild basic conditions, demonstrates potent and selective inhibitory activity against helminth complex I. However, 2 is unstable in air because the conjugated dienes are oxygen-labile. To address this, we
Towards the total synthesis of tonantzitlolone - Preparation of key fragments and the complete carbon backbone
Wittenberg, Rüdiger,Beier, Christian,Dr?ger, Gerald,Jas, Gerhard,Jasper, Christian,Monenschein, Holger,Kirschning, Andreas
, p. 4457 - 4460 (2007/10/03)
The first synthetic advances towards the novel diterpenoid tonantzitlolone 1 are described. The key steps in the synthesis involve a chromium(II) Reformatsky reaction, a diastereoselective C1 extension and an expeditious aldol coupling step of
