718629-31-3

Upstream product

• 718629-30-2 phenyl (2R)-4-{(S)-4-acetoxy-1-[(tert-butyldimethylsilyl)oxy]but-2-yl}-2-[(trimethylsilyl)ethynyl]-1,2-dihydroquinoline-1-carboxylate 
• 718629-29-9 (S)-4-acetoxy-1-[(tert-butyldimethylsilyl)oxy]-2-(quinolin-4-yl)butane 
• 718629-28-8 (S)-4-[(tert-butyldimethylsilyl)oxy]-3-(quinolin-4-yl)butanol 
• 718629-27-7 (S)-4-[(tert-butyldimethylsilyl)oxy]-3-(quinolin-4-yl)butanenitrile 
• 213478-42-3 Acetic acid (S)-3-hydroxy-2-quinolin-4-yl-propyl ester 
• 213478-44-5 (R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-quinolin-4-yl-propan-1-ol 

Downstream Products

• 718629-32-4 phenyl (2R)-4-[(R)-5-acetoxy-1,1-dibromopent-1-en-3-yl]-2-trimethylsilylethynyl-1,2-dihydroquinoline-1-carboxylate 
• 718629-34-6 phenyl (2S,3S,4R)-4-[(R)-5-[(tert-butyldimethylsilyl)oxy]-1-iodo-pent-1-yn-3-yl]-3,4-epoxy-2-iodoethynyl-3,4-dihydro-2H-quinoline-1-carboxylate 

Relevant academic research and scientific papers

Asymmetric synthesis of a new simplified dynemicin analogue equipped with a handle

The new simplified dynemicin analogue 16 was prepared enantio- and diastereoselectively in 17 steps starting from monoacetate (S) 7. It is equipped with a side arm containing a protected primary alcoholic function ('handle'), which can be used for conjugation with DNA-complexing agents or for devising new types of trigger.

Enzymatically asymmetrised chiral building blocks for the synthesis of complex natural product analogues: The synthesis of dynemicin analogues from 2-(quinolin-4-yl)propane-1, 3-diol

Full details of our synthetic approaches directed towards the enantioselective synthesis of new dynemicin analogues each containing a side-arm (a handle ) incorporating a protected alcohol are reported.