Asymmetric synthesis of a new simplified dynemicin analogue equipped with a handle

Article abstract of DOI:10.1016/j.tetlet.2004.04.029

The new simplified dynemicin analogue 16 was prepared enantio- and diastereoselectively in 17 steps starting from monoacetate (S) 7. It is equipped with a side arm containing a protected primary alcoholic function ('handle'), which can be used for conjugation with DNA-complexing agents or for devising new types of trigger.