718633-30-8Relevant articles and documents
Syntheses of novel modified acyclic purine and pyrimidine nucleosides as potential substrates of herpes simplex virus type-1 thymidine kinase for monitoring gene expression
Grote, Michaela,Noll, Steffi,Noll, Bernhard,Johannsen, Bernd,Kraus, Werner
, p. 513 - 523 (2007/10/03)
Suicide gene therapy with the herpes simplex virus type-1 thymidine kinase gene (HSV-1 tk) is considered to be a promising approach to the treatment of cancer. Making use of the lower specificity of the viral enzyme compared to human thymidine kinase, the