718638-38-1

Basic information

• Product Name: C₁₆H₁₉NO₄S₂
• Synonyms: C₁₆H₁₉NO₄S₂
• CAS NO: 718638-38-1
• Molecular Weight: 353.463
• Mol File: 718638-38-1.mol

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₉NO₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₉NO₄S₂(718638-38-1)
• EPA Substance Registry System: C₁₆H₁₉NO₄S₂(718638-38-1)

Safety Data

• Hazardous Substances Data: 718638-38-1(Hazardous Substances Data)

Upstream product

• 507-09-5 tiolacetic acid 
• 286459-94-7 4-but-2-ynyloxybenzenesulfonyl chloride 
• 718638-37-0 4-but-2-ynyloxy-N-[(R)-3-hydroxypyrrolidinyl]benzenesulfonamide 

Relevant articles and documents

Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides

A series of potent thiol-containing aryl sulfonamide TACE inhibitors was designed and synthesized. The SAR and MMP selectivity of the series were investigated. In particular, compound 4b has shown excellent in vitro potency against the isolated TACE enzym

INHIBITORS OF TACE

The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.