71883-83-5Relevant academic research and scientific papers
CHIRAL, BIOMIMETIC TOTAL SYNTHESIS OF (-)-APLYSISTATIN.
Shieh, Hong-Ming,Prestwich, Glenn D.
, p. 4643 - 4646 (1982)
The marine antineoplastic agent aplysistatin (6) has been prepared enantiospecifically.The key step is the biomimetic cyclization of (2R,3R)-2-homogeranyl-3,4-dihydroxybutanoic acid 1 4 lactone (3) with 2,4,4,6-tetrabromocyclohexa-2,5-dienone in nitromethane.
