Tetrahedron Letters p. 4643 - 4646 (1982)
Update date:2022-08-03
Topics:
Shieh, Hong-Ming
Prestwich, Glenn D.
The marine antineoplastic agent aplysistatin (6) has been prepared enantiospecifically.The key step is the biomimetic cyclization of (2R,3R)-2-homogeranyl-3,4-dihydroxybutanoic acid 1 4 lactone (3) with 2,4,4,6-tetrabromocyclohexa-2,5-dienone in nitromethane.
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Doi:10.1016/S0022-328X(02)01895-8
(2002)Doi:10.1021/ja00515a074
(1979)Doi:10.1002/hlca.19800630409
(1980)Doi:10.1021/jo01290a036
(1980)Doi:10.1002/anie.201106117
(2011)Doi:10.1002/hlca.200490075
(2004)
