71910-53-7Relevant academic research and scientific papers
Palladium-Catalyzed C?H Silylation through Palladacycles Generated from Aryl Halides
Lu, Ailan,Ji, Xiaoming,Zhou, Bo,Wu, Zhuo,Zhang, Yanghui
, p. 3233 - 3237 (2018/02/23)
A highly efficient palladium-catalyzed disilylation reaction of aryl halides through C?H activation has been developed for the first time. The reaction has broad substrate scope. A variety of aryl halides can be disilylated by three types of C?H activation, including C(sp2)?H, C(sp3)?H, and remote C?H activation. In particular, the reactions are also unusually efficient. The yields are essentially quantitative in many cases, even in the presence of less than 1 mol % catalyst and 1 equivalent of the silylating reagent under relatively mild conditions. The disilylated biphenyls can be converted into disiloxane-bridged biphenyls.
Disilylation of N-(2-Halophenyl)-2-phenylacrylamides with hexamethyldisilane via trapping the spirocyclic palladacycles
Xiao, Genhua,Chen, Liang,Deng, Guobo,Liu, Jianbing,Liang, Yun
, p. 1836 - 1840 (2018/04/11)
The palladium-catalyzed disilylation of the spirocyclic palladacycles with hexamethylaisilane has been realized. The key spirocyclic palladacycles are generated from N-(2-haloaryl)-2-arylacrylamide via intramolecular Heck reaction and followed remote C-H activation. A range of 3-((trimethylsilyl)methyl)-3-(2-(trimethylsilyl)phenyl)indolin-2-ones are obtained in good to excellent yields from readily available starting material under mild conditions.
An approach to spirooxindoles: Via palladium-catalyzed remote C-H activation and dual alkylation with CH2Br2
Shao, Changdong,Wu, Zhuo,Ji, Xiaoming,Zhou, Bo,Zhang, Yanghui
, p. 10429 - 10432 (2017/09/25)
A facile and efficient approach for the synthesis of spirooxindoles has been developed via the coupling of spirocyclic C,C-palladacycles with CH2Br2. The key spirocyclic palladacycles are generated catalytically via remote C-H activation. A range of spirooxindoles can be synthesized in good to excellent yields from readily available starting material.
Palladium-Catalyzed Spirocyclization through C?H Activation and Regioselective Alkyne Insertion
Yoon, Hyung,R?lz, Martin,Landau, Felicitas,Lautens, Mark
, p. 10920 - 10923 (2017/08/30)
A Pd-catalyzed spirocyclization involving a sequential carbopalladation, intramolecular C?H activation, and a highly regioselective alkyne insertion to afford spirooxindoles and spirodihydrobenzofurans has been achieved. The spirocyclic products were generated in good to excellent yields with complete regiocontrol in a readily scalable procedure.
