71916-55-7

Upstream product

• 50329-87-8 4-hydroxy-4-(4-methoxyphenyl)piperidine 
• 71916-50-2 Imidazol-1-yl-[4-(7-trifluoromethyl-quinolin-4-ylamino)-phenyl]-methanone 
• 71916-45-5 4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid 
• 530-62-1 1,1'-carbonyldiimidazole 
• 57975-84-5 4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid hydrochloride 
• 150-13-0 4-amino-benzoic acid 
• 346-55-4 4-chloro-7-trifluoromethyl quinoline 

Relevant academic research and scientific papers

7-(Triflluoromethyl)-4-aminoquinoline Hypotensives: Novel Peripheral Sympatholytics

A family of 7-(trifluoromethyl)-4-aminoquinolines that are hypotensive agents and that act by a novel sympatholytic mechanism is described.Structure-activity relationships in this series have been elucidated.Some of the more potent hypotensives were evalu

Antihypertensive 7-trifluoromethyl-4-aminoquinolones

Antihypertensive compounds of the formula II STR1 wherein D is a piperidino or 1,2,5,6-tetrahydropyridino ring; wherein X is chloro or trifluoromethyl; wherein R1 is hydrogen or hydroxy when the D ring is piperidino, or nothing when the D ring is 1,2,5,6-tetrahydropyridino; and, wherein the moiety Ar is 2-oxo-1-benzimidazolinyl, phenyl, or phenyl substituted by one or two halo, trifluoromethyl, or alkyl, alkoxy, in which the carbon moieties are of 1 to 3 carbon atoms, inclusive, and halo is chloro, bromo, or fluoro, are produced by reacting 4-[[7-(chloro) or (trifluoromethyl)-4-quinolinyl]-amino]benzoic acid with thionyl chloride or a carbonyl diimidazole and subsequent reaction with the selected substituted piperidine or 1,2,5,6-tetrahydropyridine. The pharmacologically acceptable acid addition salts of II can also be used as antihypertensives.