71920-53-1Relevant academic research and scientific papers
Time-Economical Radical Cascade Cyclization/Haloazidation of 1,6-Enynes: Construction of Highly Functional Succinimide Derivatives
Gu, Yan,Dai, Lei,Mao, Kaimin,Zhang, Jinghang,Wang, Chang,Zhao, Liming,Rong, Liangce
, p. 2956 - 2960 (2020)
A "time-economical" radical cascade cyclization/haloazidation of 1,6-enynes provides a direct approach to access highly functional succinimide compounds. Moderate to excellent yields along with excellent Z/E ratio were obtained under the reaction features
Synthesis of alkynamides through reaction of alkyl- or aryl-substituted alkynylaluminums with isocyanates
Cho, Soohong,Lee, Yeonjoo,Lee, Kyeongmin,Lee, Hwiwoong,Lee, Yunmi,Jung, Byunghyuck
, p. 139 - 151 (2021/12/29)
An efficient and facile method for the preparation of alkynamides through Et3N-catalyzed alumination of alkyl- or aryl-substituted terminal alkynes with AlMe3and sequential nucleophilic addition ofin situgenerated alkynylaluminums to isocyanates is described. This method has the merits of using readily available isocyanates and monosubstituted alkynes, easy access to organoaluminums, short reaction times, and high efficiency. A gram-scale synthesis of the desired alkynamide and its application to the formation of α-methylene-β-lactams demonstrates the synthetic utility of this method.
Catalytic oxidation/C-H functionalization of N-arylpropiolamides by means of gold carbenoids: Concise route to 3-acyloxindoles
Qian, Deyun,Zhang, Junliang
supporting information; experimental part, p. 7082 - 7084 (2012/08/07)
An efficient catalytic C-H functionalization by means of gold carbenoids for the one-step synthesis of 3-acyloxindole derivatives has been developed. The reaction proceeds efficiently with extremely good substrate scope and significant opportunities for s
2,5-diarylisothiazolone: Novel inhibitors of cytokine-induced cartilage destruction
Wright, Stephen W.,Petraitis, Joseph J.,Freimark, Bruce,Giannaras, John V.,Pratta, Michael A.,Sherk, Susan R.,Williams, Jean M.,Magolda, Ronald L.,Arner, Elizabeth C.
, p. 851 - 858 (2007/10/03)
A series of 2,5-diarylisothiazolones is reported that inhibit the IL-1β- induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, n
