71924-53-3

Upstream product

• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 158613-23-1 methyl 3-(trifluorosilyl)propanoate 
• 67-56-1 methanol 
• 23359-08-2 4-formylcinnamic acid 
• 40681-88-7 4-(1,3-dioxolan-2-yl)benzaldehyde 
• 115974-97-5 methyl (E)-4-carboxyl cinnamate 
• 141286-90-0 methyl (E)-3-(4-(hydroxymethyl)phenyl)acrylate 
• 619-66-9 4-Carboxybenzaldehyde 
• 7560-50-1 methyl (2E)-3-(4-formylphenyl)acrylate 
• 283153-64-0 methyl 3-(4-(hydroxymethyl)phenyl)propanoate 

Downstream Products

• 1352841-05-4 methyl 3-(4-(((triethylsilyl)oxy)methyl)phenyl)propanoate 
• 1245613-79-9 C₃₀H₂₈Cl₂F₃N₃O₄ 
• 1032671-02-5 methyl 3-(4-{[2-{2-[(benzylsulfonyl)amino]ethyl}-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]methyl}phenyl)propanoate 
• 283153-65-1 4-[2-(methoxycarbonyl)ethyl]cinnamic acid 

Relevant academic research and scientific papers

Catalytic asymmetric hydrogenation using a [2.2]paracyclophane based chiral 1,2,3-triazol-5-ylidene-Pd complex under ambient conditions and 1 atmosphere of H2

Chiral 1,2,3-triazol-5-ylidene-Pd complexes with the planar chiral [2.2]paracyclophane wing tip group have been synthesized and structurally characterized. The complex with a labile acetonitrile co-ligand is an excellent catalyst for chemoselective hydrogenation of alkynes and alkenes and enantioselective hydrogenation of prochiral alkenes at ambient conditions and 1.0 atmosphere of H2.

Reduction of Electron-Deficient Alkenes Enabled by a Photoinduced Hydrogen Atom Transfer

Direct hydrogen atom transfer from a photoredox-generated Hantzsch ester radical cation to electron-deficient alkenes has enabled the development of an efficient formal hydrogenation under mild, operationally simple conditions. The HAT-driven mechanism is supported by experimental and computational studies. The reaction is applied to a variety of cinnamate derivatives and related structures, irrespective of the presence of electron-donating or electron-withdrawing substituents in the aromatic ring and with good functional group compatibility. (Figure presented.).

HDAC INHIBITORS

Compounds of formula (I) inhibit HDAC activity, wherein A, B and D independently represent =C- or =N-; W is a divalent radical -CH=CH- or CH2CH2-; R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; z is 0 or 1; and Y, L1, and X1 are as defined in the claims.

Cinnamamide derivatives and drug compositions containing the same

The invention relates to cinnamamide derivatives having the following formula wherein R1represents a hydroxyl group, a C1-6-alkoxy group, an arylalkoxy group or a substituted or unsubstituted amino group; R2and R3are same or different, each of which represents a hydrogen atom, a halogen atom or a C1-4-alkyl group; R4represents a hydrogen atom or a C1-6-alkyl group; R5represents a hydrogen atom, a C1-6-alkyl group or an aryl group; R6represents a hydrogen atom, a C1-6-alkyl group, a cyano group or a C1-6-alkoxy-carbonyl group; W represents an oxygen atom, a sulfur atom, an imino group, a methylene group, a hydroxymethylene group or a carbonyl group; X and Y are same or different, each of which represents an oxygen atom or a sulfur atom; m represents an integer of 0 to 2; n represents an integer of 1 to 3; and when m is 0, a group: —C(R2)(R3)—W— may represent a vinylene group; or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the above compound, in particular, an immunomodulatory agent and a prophylactic or therapeutic agent for nephrotic syndrome, circulatory disorders or respiratory diseases.

Palladium-Catalyzed Cross-Coupling Reaction of Alkyltrifluorosilanes with Aryl Halides

A cross-coupling reaction of alkyltrifluorosilanes with aryl halides was achieved using a catalytic amount of tetrakis-(triphenylphosphine)palladium(0) and excess of tetrabutylammonium fluoride (TBAF) at 100°C with high chemoselectitvity. Functional groups like nitro, ketone carbonyl, and formyl tolerated the coupling conditions. Because potassium(18-crown-6) alkyltetrafluorosilicates also underwent a cross-coupling reaction in the presence of an additional molar amount of TBAF, the active species of the coupling reaction was assumed to be pentacoordinate silicates. TBAF in excess was considered to be required for trapping the tetrafluorosilane produced in the catalytic cycle of the cross-coupling reaction.

Palladium catalyzed cross-coupling reaction of functionalized alkyltrifluorosilanes with aryl halides

A variety of alkyltrifluorosilanes were found to couple with aryl halides in the presence of Pd(PPh3)4 catalyst and tetrabutylammonium fluoride (TBAF) to give the corresponding cross-coupled products in moderate to good yields.

Novel compounds

A compound of formula (I): STR1 or a salt, ester or amide thereof, in which Y is a group --O(CH2)m --, --(CH2)m -- or --CH=CH-- where m is an integer of from 1 to 5 n is an integer of from 4 to 14 X represents a double or triple bond, and each of A and B represents hydrogen when X is a double bond, or both A and B are absent when X is a triple bond, is useful in the treatment of allergic diseases.