71925-03-6Relevant academic research and scientific papers
β-(Cycloalkylamino)ethanesulfonyl azides as novel water-soluble reagents for the synthesis of diazo compounds and heterocycles
Shafran, Yuri M.,Silaichev, Pavel S.,Bakulev, Vasiliy A.
, p. 1251 - 1261 (2020/01/11)
[Figure not available: see fulltext.] Novel water-soluble sulfonyl azides were synthesized, which are basic by nature. The obtained compounds were used as donors of the diazo group in the diazo transfer reaction. Due to their good solubility in water and high polarity, the byproducts formed in this case were easily separated from the desired products by washing with water or column chromatography. It was also shown that new sulfonyl azides as a result of reactions can be incorporated in heterocyclic products, imparting them water solubility.
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3- triazoles
Smith, Catherine J.,Nikbin, Nikzad,Ley, Steven V.,Lange, Heiko,Baxendale, Ian R.
, p. 1938 - 1947 (2011/04/24)
Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a
