719312-18-2Relevant academic research and scientific papers
Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor
Thomson, Douglas W.,Poeckel, Daniel,Zinn, Nico,Rau, Christina,Strohmer, Katrin,Wagner, Anne J.,Graves, Alan P.,Perrin, Jessica,Bantscheff, Marcus,Duempelfeld, Birgit,Kasparcova, Viera,Ramanjulu, Joshi M.,Pesiridis, G. Scott,Muelbaier, Marcel,Bergamini, Giovanna
, p. 780 - 785 (2019)
The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, energy homeostasis, autophagy, and neuroinflammation. Herei
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration
Drewry, David H.,Annor-Gyamfi, Joel K.,Wells, Carrow I.,Pickett, Julie E.,Dederer, Verena,Preuss, Franziska,Mathea, Sebastian,Axtman, Alison D.
, p. 1313 - 1328 (2021/08/24)
The pyrimidine core has been utilized extensively to construct kinase inhibitors, including eight FDA-approved drugs. Because the pyrimidine hinge-binding motif is accommodated by many human kinases, kinome-wide selectivity of resultant molecules can be p
TBK1 INHIBITOR COMPOUNDS
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Page/Page column 21, (2019/12/28)
The present invention relates to compounds of formula I, and pharmaceutical salts thereof, and their use as TBK1 inhibitors. The invention also provides methods of introducing nucleic acids into a cell, changing the genotype of a cell and animal cells pro
COMPOUNDS FOR THE TREATMENT OF ABNORMAL CELL GROWTH
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Page 55, (2008/06/13)
The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R4, R5, n, A and B are as defined herein. The inventi
