7195-78-0

Usage

Uses

Used in Pharmaceutical Industry:
5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE is used as a reagent and intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical properties make it a valuable building block in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE is utilized as a reagent and intermediate for the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals.
Used in Research and Laboratory Settings:
5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE is used as a research compound in various scientific studies and laboratory experiments. Its unique properties make it a valuable tool for exploring new chemical reactions and synthesizing novel organic compounds.
Used in Material Science:
5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE has potential applications in the development of new materials due to its unique chemical and physical properties. It can be used as a component in the synthesis of advanced materials with specific properties for various applications.
Used in Medicinal Chemistry for Drug Discovery:
In the field of medicinal chemistry, 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE is employed as a starting material for the discovery and development of new drugs. Its unique structure and properties make it a promising candidate for the design of novel therapeutic agents.

InChI:InChI=1/C8H6ClNO5/c1-4(11)6-2-5(9)3-7(8(6)12)15-10(13)14/h2-3,12H,1H3

Upstream product

• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 

Downstream Products

• 124071-19-8 5-Chloro-2-hydroxy-3-nitro-N-tetradecyl-benzamide 
• 159323-96-3 ethyl 5-chloro-2-hydroxy-3-nitrobenzoate 
• 149140-78-3 ethyl 3-aminio-5-chloro-2-hydroxybenzoate 
• 570-23-0 3-aminosalicylic acid 

Relevant academic research and scientific papers

Design and synthesis of 5-chloro-2-hydroxy-3-triazolylbenzoic acids as HIV integrase inhibitors

A series of potential HIV-1 integrase inhibitors based on 5-chloro-2-hydroxy-3-triazolylbenzoic acid scaffold was designed and synthesized. Some of these compounds exhibit potent inhibitory activities at micromolar concentrations against HIV-1 integrase i

3-process for the preparation of amino-salicylic acid

The invention relates to a novel preparation method of 3-aminosalicylic acid. The novel preparation method is characterized in that a salicylic acid compound I as an initial raw material having a general formula shown in the description and a nitration agent undergo a reaction to produce a 3-nitrosalicylic acid compound II having a general formula shown in the description, and the 3-nitrosalicylic acid compound II undergoes nitryl catalytic hydrogenation reduction and dehalogenation hydrogenolysis reactions in the presence of an effective dose of a catalyst and hydrogen donors so that 3-aminosalicylic acid is produced.

Development of a Phase-Transfer-Catalyzed, [2,3]-Wittig Rearrangement

An investigation into the use of phase-transfer catalysis for the [2,3]-sigmatropic rearrangement of allyloxy carbonyl compounds is described. Initial studies focused on identifying viable substrate classes that would undergo selective [2,3]-rearrangement under phase-transfer catalysis. Under certain conditions, the [2,3]-sigmatropic rearrangement of allyloxy carbonyl compounds takes place in the presence of a phase-transfer agent, providing a rare example of a phase-transfer-catalyzed unimolecular reaction. In the course of this investigation, it was found that catalysis is dependent on several variables including base concentration, catalyst structure, and substrate lipophilicity. Preliminary testing of chiral, nonracemic phase-transfer catalysts has shown promising levels of enantioselectivity for future development.

Fungicidal compositions and methods, and compounds and methods for the preparation thereof

Fungicidal compositions and methods comprising acylated aminosalicylamides (AASA) described herein. Novel cyclic amines and 3-nitrosalicylamides, and their use as pesticides and in the preparation of the antifungal AASA compounds are also disclosed.

Synthesis and Enzymatic Evaluation of Conformationally Defined Carnitine Analogs

Carnitine (1, 3-hydroxy-4-trimethylammoniobutyrate) is essential as a donor and acceptor of acyl groups in cellular metabolism.The major solution conformation of carnitine about C3-C4 contains the gauche reletionship between the trimethylammonium and hydr