7195-78-0

Basic information

• Product Name: 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE
• Synonyms: LABOTEST-BB LT00452353;2-ACETYL-6-NITRO-4-CHLORO PHENOL;AKOS BB-6935;2-ACETYL-4-CHLORO-6-NITROPHENOL
• CAS NO: 7195-78-0
• Molecular Formula: C₇H₄ClNO₅
• Molecular Weight: 215.59
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 7195-78-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 132-135 °C(lit.)
• Boiling Point: 357oC at 760 mmHg
• Flash Point: 169.7oC
• Appearance: /
• Density: 1.527g/cm3
• Vapor Pressure: 1.37E-05mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE(7195-78-0)
• EPA Substance Registry System: 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE(7195-78-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 7195-78-0(Hazardous Substances Data)

Usage

General Description

5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE is a chemical compound that belongs to the class of acetophenone derivatives. It is a yellow crystalline solid with a molecular formula C8H6ClNO4 and a molecular weight of 203.59 g/mol. 5'-CHLORO-2'-HYDROXY-3'-NITROACETOPHENONE is commonly used in research and laboratory settings as a reagent and intermediate for the synthesis of various organic compounds. Its chemical properties make it a useful building block for the preparation of pharmaceuticals and agrochemicals. Additionally, it has potential applications in the development of new materials and in medicinal chemistry for drug discovery. The presence of a chloro, hydroxy, and nitro group in its chemical structure gives it unique chemical and physical properties that make it valuable for scientific and industrial purposes.

InChI:InChI=1/C8H6ClNO5/c1-4(11)6-2-5(9)3-7(8(6)12)15-10(13)14/h2-3,12H,1H3

Upstream product

• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 

Downstream Products

• 570-23-0 3-aminosalicylic acid 
• 149140-78-3 ethyl 3-aminio-5-chloro-2-hydroxybenzoate 
• 7180-80-5 3-amino-5-chloro-2-hydroxybenzoic acid 

Relevant articles and documents

Design and synthesis of 5-chloro-2-hydroxy-3-triazolylbenzoic acids as HIV integrase inhibitors

A series of potential HIV-1 integrase inhibitors based on 5-chloro-2-hydroxy-3-triazolylbenzoic acid scaffold was designed and synthesized. Some of these compounds exhibit potent inhibitory activities at micromolar concentrations against HIV-1 integrase i

Development of a Phase-Transfer-Catalyzed, [2,3]-Wittig Rearrangement

An investigation into the use of phase-transfer catalysis for the [2,3]-sigmatropic rearrangement of allyloxy carbonyl compounds is described. Initial studies focused on identifying viable substrate classes that would undergo selective [2,3]-rearrangement under phase-transfer catalysis. Under certain conditions, the [2,3]-sigmatropic rearrangement of allyloxy carbonyl compounds takes place in the presence of a phase-transfer agent, providing a rare example of a phase-transfer-catalyzed unimolecular reaction. In the course of this investigation, it was found that catalysis is dependent on several variables including base concentration, catalyst structure, and substrate lipophilicity. Preliminary testing of chiral, nonracemic phase-transfer catalysts has shown promising levels of enantioselectivity for future development.

Synthesis and Enzymatic Evaluation of Conformationally Defined Carnitine Analogs

Carnitine (1, 3-hydroxy-4-trimethylammoniobutyrate) is essential as a donor and acceptor of acyl groups in cellular metabolism.The major solution conformation of carnitine about C3-C4 contains the gauche reletionship between the trimethylammonium and hydr