71972-61-7Relevant academic research and scientific papers
An unexpected thermal [1,3]-[1,3]-para rearrangement of chromone-3-ylmethyl aryl ethers: Mechanism and application of the intercepted [1,3]-rearranged intermediates to the synthesis of cis-homopterocarpans
Devarajan, Krishnan,Devaraj, Somasundaram,Balasubramanian, Kalpattu K.,Bhagavathy, Shanmugasundaram
supporting information, p. 551 - 553 (2015/05/27)
Chromone-3-ylmethyl aryl ethers with unsubstituted orthopositions have been found to undergo a novel domino [1,3]-[1,3]-rearrangement to give 4′-hydroxyhomoisoflavones under thermal conditions while the para-substituted ethers lead to 2′-hydroxyhomoisofla
Structure-cytotoxic activity relationship of 3-arylideneflavanone and chromanone (E,Z isomers) and 3-arylflavones
Kupcewicz, Bogumi?a,Balcerowska-Czerniak, Grazyna,Ma?ecka, Magdalena,Paneth, Piotr,Krajewska, Urszula,Rozalski, Marek
, p. 4102 - 4106 (2013/07/26)
The E,Z-isomers of 3-arylidene substituted flavanone, chromanone and 3-aryl substituted flavone derivatives were tested in vitro for their cytotoxic activity against three cancer cell lines (HL-60, NALM-6, WM-115) and normal cell line (HUVEC). It was observed that substitution at C3 position led to significant enhance in cytotoxicity. Isomeric configuration of 3-arylideneflavanones had an influence on the cytotoxic potential. Multiple regression analysis combined with variable selection by genetic algorithm was used to model relationships between molecular descriptors and the cytotoxic activity. The most accurate QSAR models were based on a combination between energy of LUMO, experimental value of log P and partial charge on carbonyl oxygen (δO2).
