525-82-6

Basic information

• Product Name: FLAVONE
• Synonyms: Cromaril;DA6034;Flavon;Phenylchromone;Flavone(2-Phenylchromone);FLAVONE, CRYSTALLIZED, SYNTHETIC;Flavone,99%;FLAVONE extrapure
• CAS NO: 525-82-6
• Molecular Formula: C₁₅H₁₀O₂
• Molecular Weight: 222.24
• EINECS: 208-383-8
• Product Categories: Biochemistry;Flavonoids;Building block;Inhibitors
• Mol File: 525-82-6.mol
• Article Data: 267

Chemical Properties

• Melting Point: 94-97 °C(lit.)
• Boiling Point: 185 °C / 1mmHg
• Flash Point: 171.058 °C
• Appearance: White/Crystalline Powder
• Density: 1.1404 (rough estimate)
• Vapor Pressure: 1.41E-05mmHg at 25°C
• Refractive Index: 1.6600 (estimate)
• Storage Temp.: Store below +30°C.
• Water Solubility: Soluble in acetone (25 mg/ml), methanol, alcohol, and chloroform. Insoluble in water.
• Merck: 14,4092
• BRN: 157598
• CAS DataBase Reference: FLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: FLAVONE(525-82-6)
• EPA Substance Registry System: FLAVONE(525-82-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: DJ3100630
• TSCA: Yes
• Hazardous Substances Data: 525-82-6(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

Uses

Flavone is a potentially useful biochemical for cytochrome P450 studies.

Definition

One of a group of flavonoid plant pigments existing as colorless needles, that are insoluble in water and melting at 100C. It fluoresces violet in concentrated sulfuric acid. It can be synthesized. Treatment with alcoholic alkali yields flavanone. The fla

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 689, 1957 DOI: 10.1021/ja01560a050The Journal of Organic Chemistry, 44, p. 497, 1979 DOI: 10.1021/jo01318a005Tetrahedron Letters, 31, p. 4073, 1990 DOI: 10.1016/S0040-4039(00)94503-9

Purification Methods

Dissolve it in dilute aqueous NaOH, filter and precipitate it by adding dilute (1:1) HCl. The process is repeated twice more, and the fluorescein is dried at 100o. Alternatively, it has been crystallised from acetone by allowing the solution to evaporate at 37o in an open beaker. It has also been recrystallised from EtOH and dried in a vacuum oven. [Beilstein 19 I 721, 19 II 248, 19 III/IV 2904, 19/8 V 456.]

InChI:InChI=1/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H

Synthetic route

1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione (1469-94-9) → FLAVONE (525-82-6)

Conditions	Yield
copper dichloride In ethanol at 80℃; for 0.0833333h; microwave irradiation;	98%
With potassium hydrogensulfate at 120℃; for 2h; Temperature; Green chemistry;	98%
With gallium(III) triflate In nitromethane at 80℃; for 2h;	97%

2-Iodophenol (533-58-4) + carbon monoxide (201230-82-2) + phenylacetylene (536-74-3) → FLAVONE (525-82-6)

Conditions	Yield
With C22H28Br2N4Pd; diethylamine In N,N-dimethyl-formamide at 80℃; under 3000.3 Torr; for 24h; Autoclave;	98%
With diethylamine In N,N-dimethyl-formamide at 100℃; under 10343.2 Torr; for 24h; Sonogashira Cross-Coupling; Autoclave;	96%
With (trihexyl)(tetradecyl)phosphonium bromide; triethylamine; palladium dichloride at 110℃; under 760.051 Torr; for 24h; Autoclave;	95%

benzaldehyde (100-52-7) + 1-phenyl-2-hydroxyethanone (582-24-1) → FLAVONE (525-82-6)

Conditions	Yield
With 1-butyl-3-methylimidazolium molybdate In hexan-1-ol at 70℃; for 3h;	98%

Flavanone (487-26-3) → FLAVONE (525-82-6)

Conditions	Yield
With pyrrolidone hydrotribromide In dimethyl sulfoxide at 80℃; for 2h;	97%
With thallium(III) acetate In acetic acid for 3h; Heating;	96%
With thallium(III) acetate In acetic acid for 3h; Heating;	96%

(E)-2'-hydroxy-chalcone (888-12-0) → FLAVONE (525-82-6)

Conditions	Yield
With indium(III) bromide; silica gel at 130 - 140℃; for 0.75h;	96%
With iodine In dimethyl sulfoxide for 1h; Reflux;	85%
With iodine In 2,2'-[1,2-ethanediylbis(oxy)]bisethanol at 150℃; for 4h; Product distribution; Further Variations:; Solvents; Temperatures; reaction times;	83%

1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one (16619-68-4) → FLAVONE (525-82-6)

Conditions	Yield
With dmap In N,N-dimethyl-formamide at 0 - 30℃; for 1.5h; Morita-Baylis-Hillman reaction; Inert atmosphere; regioselective reaction;	96%
With thallium(III) toluene-p-sulfonate In methanol at 65℃; for 6h; Reagent/catalyst; Solvent; Time; regioselective reaction;	91%
With lithium tert-butoxide In N,N-dimethyl-formamide at 20℃; for 0.166667h; Reagent/catalyst; Time; Temperature;	90%

1-(2-hydroxyphenyl)-2-(triphenylphosphoranylidene)ethanone (81995-11-1) + benzoyl chloride (98-88-4) → FLAVONE (525-82-6)

Conditions	Yield
With pyridine In toluene for 5h; Heating;	96%

1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (1214-47-7) → FLAVONE (525-82-6)

Conditions	Yield
With Iodine monochloride; dimethyl sulfoxide at 50℃; for 0.5h; Temperature; Reagent/catalyst; Sonication; Green chemistry;	96%
With cerium (IV) sulfate tetrahydrate; silica gel In neat (no solvent) at 100℃; for 4h; Concentration; Time; Green chemistry;	94%
With copper(l) iodide; oxygen at 50℃; under 760.051 Torr; for 48h; oxa-Michael-oxidation; Ionic liquid;	92%

1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-one (223511-19-1) → FLAVONE (525-82-6)

Conditions	Yield
With diethylamine In ethanol for 24h; Heating;	96%

2'-allyloxychalcone (16619-51-5) → FLAVONE (525-82-6)

Conditions	Yield
With iodine In dimethyl sulfoxide at 120℃; for 0.5h; regioselective reaction;	96%
Multi-step reaction with 2 steps 1: acetic acid / 24 h / 20 °C 2: iodine / dimethyl sulfoxide / 0.5 h / 130 °C View Scheme

2,3-dihydro-4H-1-benzopyran-4-one (491-37-2) + phenylboronic acid (98-80-6) → FLAVONE (525-82-6)

Conditions	Yield
With palladium(II) trifluoroacetate; 5-Nitro-1,10-phenanthroline; oxygen In dimethyl sulfoxide at 100℃; for 48h; Reagent/catalyst; Solvent;	96%

1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one (16619-68-4) → FLAVONE (525-82-6) + (Z)-4'-methoxyaurone (36685-41-3)

Conditions	Yield
With silver nitrate In methanol Ambient temperature;	A 5% B 95%

1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one (16619-68-4) → FLAVONE (525-82-6) + aurone (37542-14-6)

Conditions	Yield
With silver nitrate In methanol Ambient temperature;	A 5% B 95%
With 2-pyridone sodium salt In tetrahydrofuran at 20℃; for 6h; Reagent/catalyst; Solvent; Temperature; Time; regioselective reaction;	A 3% B 93%
With tricyclohexylphosphine In ethanol at 30℃; for 2h;	A n/a B 55%

1-(2-acetoxy-phenyl)-3-phenyl-2-propyn-1-one (16619-67-3) → FLAVONE (525-82-6)

Conditions	Yield
With piperazine In acetonitrile at 25℃; for 3h; Schlenk technique;	95%
With piperazine In acetonitrile at 20℃; for 6h; Schlenk technique;	95%
With 18-crown-6 ether; potassium methanolate In tetrahydrofuran at 20℃; for 0.25h; Reagent/catalyst; Time; Temperature; Solvent;	76%

iron pentacarbonyl (13463-40-6) + 2-Iodophenol (533-58-4) + phenylacetylene (536-74-3) → FLAVONE (525-82-6)

Conditions	Yield
With piperazine; palladium diacetate In acetonitrile at 50℃; for 12h; Schlenk technique;	95%

2-phenylchromene (93514-42-2, 6053-99-2) → FLAVONE (525-82-6)

Conditions	Yield
With tert.-butylhydroperoxide; copper(ll) bromide In decane; toluene at 80℃; for 0.0833333h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;	94%
With thallium(III) nitrate In methanol Ambient temperature; overnight;	20%

1-benzopyran-4(4H)-one (491-38-3) + phenylboronic acid (98-80-6) → FLAVONE (525-82-6)

Conditions	Yield
Stage #1: 1-benzopyran-4(4H)-one; phenylboronic acid With iron(III) trifluoromethanesulfonate; palladium diacetate; Trimethylacetic acid at 60℃; under air; Stage #2: With potassium nitrite; 2,3-dicyano-5,6-dichloro-p-benzoquinone	94%
Stage #1: 1-benzopyran-4(4H)-one With 1,10-Phenanthroline; oxygen; palladium diacetate In N,N-dimethyl-formamide for 0.0833333h; Heck type reaction; Stage #2: phenylboronic acid In N,N-dimethyl-formamide at 100℃; for 24h; Heck type reaction; regioselective reaction;	86%

2,3-dihydro-4H-1-benzopyran-4-one (491-37-2) + 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole (24388-23-6) → FLAVONE (525-82-6)

Conditions	Yield
With palladium(II) trifluoroacetate; 5-Nitro-1,10-phenanthroline; oxygen In dimethyl sulfoxide at 100℃; for 48h;	93%
With palladium(II) trifluoroacetate; 5-Nitro-1,10-phenanthroline; oxygen In dimethyl sulfoxide at 100℃; Heck Reaction;	93%

2'-benzyloxy-2-bromo-acetophenone (36695-24-6) → FLAVONE (525-82-6) + 2-acetylphenyl benzoate (4010-33-7)

Conditions	Yield
pyrex In benzene Irradiation;	A 4% B 92%

2-iodophenyl acetate (32865-61-5) + carbon monoxide (201230-82-2) + phenylacetylene (536-74-3) → FLAVONE (525-82-6)

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; thiourea; bis-triphenylphosphine-palladium(II) chloride; 1,3-bis-(diphenylphosphino)propane at 40℃; for 48h; Addition; cyclization;	92%

3-iodo-2-phenyl-4H-1-benzopyran-4-one (98153-12-9) → FLAVONE (525-82-6)

Conditions	Yield
With sodium formate; bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 90℃;	92%
With copper(l) iodide; potassium carbonate; isopropyl alcohol at 90℃; for 12h; Green chemistry; regioselective reaction;	92%

4-oxo-2-phenyl-4H-chromen-6-yl 4-methylbenzenesulfonate (137527-18-5) → FLAVONE (525-82-6)

Conditions	Yield
With dimethylamine borane; potassium carbonate; triphenylphosphine; nickel In N,N-dimethyl-formamide at 120℃; for 12h;	92%

3-bromo-2-phenyl-chromen-4-one (1025-86-1) → FLAVONE (525-82-6)

Conditions	Yield
With copper(l) iodide; potassium carbonate; isopropyl alcohol at 90℃; for 12h; Catalytic behavior; Reagent/catalyst; Green chemistry; regioselective reaction;	92%

trans-3-mesyloxyflavanone (67139-31-5) → FLAVONE (525-82-6) + aurone (37542-14-6)

Conditions	Yield
With dibutylamine In dimethyl sulfoxide for 72h; Ambient temperature;	A 91.5% B 6.2%
With sodium acetate In dimethyl sulfoxide at 25℃; for 144h;	A 80.1% B 10.9%
With sodium acetate In dimethyl sulfoxide at 25℃; for 144h; Product distribution; other reaction temperatures, solvents, reaction time, reagents, catalists, other amount of catalists and use other 3-mesyloxy-flavanone;	A 80.1% B 10.9%
With potassium cyanate; 18-crown-6 ether In benzene for 21h; Heating;	A 31.3% B 48%
With isopropylamine In dimethyl sulfoxide for 72h; Ambient temperature;	A 57.5 % Spectr. B 32.9 % Spectr.

1-(2-Hydroxy-4-methoxyphenyl)-3-phenylpropyn-1-one (98153-26-5) → FLAVONE (525-82-6) + 7-methoxoyflavone (22395-22-8)

Conditions	Yield
With silver nitrate In methanol Ambient temperature;	A 91% B n/a

3-<(4-Methylphenyl)sulphinyl>-4H-1-benzopyran-4-one (108378-93-4) + phenylmagnesium bromide → FLAVONE (525-82-6)

Conditions	Yield
With copper(I) bromide dimethylsulfide complex In tetrahydrofuran at -78 - 0℃; for 2.5h;	91%

1-(2'-bromophenyl)-3-phenylpropane-1,3-dione (36081-80-8) → FLAVONE (525-82-6)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 1h; Ullmann type reaction; under air;	91%
With tert-butylisonitrile; palladium diacetate; potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether In N,N-dimethyl-formamide at 120℃; for 2h; Reagent/catalyst; Solvent; chemoselective reaction;	86%

C18H16Br2O2 (1657006-73-9) → FLAVONE (525-82-6)

Conditions	Yield
With iodine In dimethyl sulfoxide at 130℃; for 0.5h;	91%

4-thioflavone (5465-04-3) → FLAVONE (525-82-6)

Conditions	Yield
With Clayfen for 0.025h; microwave irradiation;	90%
With tetraethylammonium perchlorate; ethidium Bromide In N,N-dimethyl-formamide cathodic reduction;
With air In ethanol at 20℃; Photolysis;

2'-hydroxychalcone dichloride (75630-53-4) → FLAVONE (525-82-6)

Conditions	Yield
at 210 - 220℃; for 1.5h;	90%

FLAVONE (525-82-6) → 1a,7a-Dihydro-1a-phenyl-7H-oxireno<1>benzopyran-7-one (134051-30-2)

Conditions	Yield
With 3,3-dimethyldioxirane In dichloromethane; acetone at 0℃; for 36h;	100%
With 3,3-dimethyldioxirane In dichloromethane; acetone at 0℃; for 36h;	100%
With Oxone; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate In acetonitrile at 0 - 1℃; for 1.25h;	99%

FLAVONE (525-82-6) + 2,2,2-trifluoroethyl acrylate (407-47-6) → 2,2,2-trifluoroethyl (E)-3-(2-phenyl-4-oxo-4H-chromen-5-yl)acrylate

Conditions	Yield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate In tert-Amyl alcohol at 20 - 100℃; for 12.33h; Schlenk technique; Sealed tube; regioselective reaction;	99%

FLAVONE (525-82-6) → (2S)-flavanone (487-26-3, 17002-31-2, 24271-98-5, 27439-12-9) + (R)-flavanone (487-26-3, 17002-31-2, 24271-98-5, 27439-12-9)

Conditions	Yield
Stage #1: FLAVONE With Dimethylphenylsilane; C50H52N2; bis(pentafluorophenyl)borohydride In toluene at 20℃; for 1h; Inert atmosphere; Glovebox; Stage #2: With trifluoroacetic acid In toluene at 20℃; for 0.166667h; Inert atmosphere; Glovebox; enantioselective reaction;	A n/a B 99%

FLAVONE (525-82-6) + diethylstilbestrol (56-53-1) → C18H20O2*2C15H10O2

Conditions	Yield
In methanol at 20℃; Solvent;	98.72%

FLAVONE (525-82-6) → 3-chloro-2-phenyl-chromen-4-one (13178-98-8)

Conditions	Yield
With sulfuryl dichloride; Montmorillonite-K-10 clay In dichloromethane for 0.25h; Ambient temperature;	98%
With pyridine; chloro-trimethyl-silane; [bis(acetoxy)iodo]benzene In dichloromethane at 0℃; for 3.5h;	82%
With sulfuryl dichloride In tetrachloromethane	63%

FLAVONE (525-82-6) → (2R*,2’R*)-2,2’-diphenyl-[2,2’-bichromane]-4,4’-dione (71840-34-1, 71840-35-2, 82908-23-4)

Conditions	Yield
With samarium diiodide In tetrahydrofuran; methanol at -40℃; for 24h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; stereoselective reaction;	98%

FLAVONE (525-82-6) → (2R*,2’S*)-2,2’-diphenyl-[2,2’-bichromane]-4,4’-dione (71840-35-2)

Conditions	Yield
With samarium diiodide In tetrahydrofuran; methanol at 68℃; for 24h; Inert atmosphere; stereoselective reaction;	98%

FLAVONE (525-82-6) → 3-Mercapto-2-phenyl-4H-1-benzopyran-4-one (98153-13-0)

Conditions	Yield
With sulfur; lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.583333h;	97%

FLAVONE (525-82-6) → 2-phenyl-chroman-4-ol (487-25-2, 20107-47-5, 20107-48-6, 20902-95-8, 26049-32-1, 27439-08-3, 41886-75-3, 51196-78-2, 51196-83-9)

Conditions	Yield
With methanol; sodium tetrahydroborate; cobalt(II) 5,10,15,20-tetraphenylporphyrin; oxygen at 20℃; for 0.166667h; Kinetics; Reagent/catalyst; Time;	97%

FLAVONE (525-82-6) → 2-phenylchromanol

Conditions	Yield
With sodium tetrahydroborate In methanol at 20℃; for 3h; Inert atmosphere;	95%

4-toluenesulfonyl azide (941-55-9) + FLAVONE (525-82-6) → 4-methyl-N-(4-oxo-2-phenyl-4H-chromen-5-yl)benzenesulfonamide (1607017-87-7)

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium carbonate; acetic acid; silver(I) triflimide In 1,2-dichloro-ethane at 25℃; for 12h; Inert atmosphere;	95%

FLAVONE (525-82-6) → 3-(2-hydroxyphenyl)-5-phenyl-pyrazole (19726-12-6)

Conditions	Yield
With hydrazine hydrate In ethanol at 90℃;	95%

N-methylmaleimide (930-88-1) + FLAVONE (525-82-6) → 1-methyl-3-(4-oxo-2-phenyl-4H-chromen-5-yl)pyrrolidine-2,5-dione

Conditions	Yield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; Trimethylacetic acid In 1,2-dichloro-ethane at 80℃; for 20h; Sealed tube;	94%

Upstream product

• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 108-95-2 phenol 
• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 107-03-9 1-thiopropane 
• 67139-31-5 trans-3-mesyloxyflavanone 
• 109365-86-8 1-(o-hydroxyphenyl)-3-phenylpropargylic alcohol 
• 90-02-8 salicylaldehyde 
• 536-74-3 phenylacetylene 
• 69404-96-2 methyl-2-<(tert-butyldimethylsilyl)oxy>benzoate 
• 108-86-1 bromobenzene 
• 201230-82-2 carbon monoxide 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 89285-88-1 1,3-dimethyl-5-(2-phenyl-chromen-4-ylidene)-pyrimidine-2,4,6-trione 
• 5465-04-3 4-thioflavone 
• 134150-76-8 1-(4-Methoxy-phenyl)-1-oxo-2a-phenyl-1H,2aH-2,3-dioxa-1λ⁵-phospha-cyclobuta[b]naphthalene-8-thiol 
• 94194-00-0 3-hydroxy-2-methoxyflavanone dimethylacetal 
• 88187-02-4 3-bromo-2-methoxyflavan-4-one 
• 98153-11-8 2-phenyl-3-(trimethylsilyl)-4H-chromen-4-one 
• 87287-73-8 Z-2-(1,3-diphenyl-3-hydroxy-1-pentenyl)phenol 
• 66406-71-1 3-bromo-2-ethoxyflavan-4-one 
• 56986-80-2 3-Methylthio-2-phenyl-4H-1-benzopyran-4-one 
• 77037-45-7 4-oxo-2-phenyl-4H-1-benzopyran-3-carboxylic acid 
• 82381-51-9 2-((Z)-1-Ethyl-3-hydroxy-3-phenyl-pent-1-enyl)-phenol 
• 88187-08-0 2-acetoxy-3-bromoflavan-4-one 
• 77902-85-3 C₁₆H₁₃O₂⁽¹⁺⁾*BF₄^(1-) 
• 92736-17-9 N⁽²⁾,N'(2')-propanediyl-1,3 bis(amino-2 o-hydroxyphenyl-4 phenyl-6 pyrimidine) 

Relevant articles and documents

Chapter Open for the Excited-State Intramolecular Thiol Proton Transfer in the Room-Temperature Solution

We report here, for the first time, the experimental observation on the excited-state intramolecular proton transfer (ESIPT) reaction of the thiol proton in room-temperature solution. This phenomenon is demonstrated by a derivative of 3-thiolflavone (3TF), namely, 2-(4-(diethylamino)phenyl)-3-mercapto-4H-chromen-4-one (3NTF), which possesses an - S - H···O= intramolecular H-bond (denoted by the dashed line) and has an S1 absorption at 383 nm. Upon photoexcitation, 3NTF exhibits a distinctly red emission maximized at 710 nm in cyclohexane with an anomalously large Stokes shift of 12 230 cm-1. Upon methylation on the thiol group, 3MeNTF, lacking the thiol proton, exhibits a normal Stokes-shifted emission at 472 nm. These, in combination with the computational approaches, lead to the conclusion of thiol-type ESIPT unambiguously. Further time-resolved study renders an unresolvable (180 fs) ESIPT rate for 3NTF, followed by a tautomer emission lifetime of 120 ps. In sharp contrast to 3NTF, both 3TF and 3-mercapto-2-(4-(trifluoromethyl)phenyl)-4H-chromen-4-one (3FTF) are non-emissive. Detailed computational approaches indicate that all studied thiols undergo thermally favorable ESIPT. However, once forming the proton-transferred tautomer, the lone-pair electrons on the sulfur atom brings non-negligible nπ? contribution to the S1′ state (prime indicates the proton-transferred tautomer), for which the relaxation is dominated by the non-radiative deactivation. For 3NTF, the extension of π-electron delocalization by the diethylamino electron-donating group endows the S1′ state primarily in the ππ? configuration, exhibiting the prominent tautomer emission. The results open a new chapter in the field of ESIPT, covering the non-canonical sulfur intramolecular H-bond and its associated ESIPT at ambient temperature.

A novel one-pot synthesis of flavones

In this paper, a one-pot facile route for the BiCl3/RuCl3-mediated synthesis of functionalized flavones is described, including: (i) intermolecularortho-acylation of substituted phenols with cinnamoyl chlorides, and (ii) intramolecular cyclodehydrogenation of the resultingo-hydroxychalcones. The reaction conditions are discussed herein.

METHOD FOR SYNTHESIZING (Z)-AURONE AND DERIVATIVE COMPOUNDS THEREOF

One embodiment of the present invention is described below. Provided is (Z)-operon comprising o - (alkanone -1 - yl) phenol or its derivative compound in a thallium (Tl) catalyst and an cyclization step for cyclizing the compound under an organic solvent, and a method for producing the derivative compound.