71078-55-2

Upstream product

• 219766-77-5 5-[4-(benzyloxy)phenoxy]-2-nitropyridine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 123-31-9 hydroquinone 
• 87789-44-4 4-(5'-nitropyrid-2'-yloxy)phenyl tert.-butyl ether 
• 103-16-2 4-Benzyloxyphenol 
• 71973-03-0 2-(4-methoxyphenoxy)-5-nitropyridine 

Downstream Products

• 639091-65-9 5-nitro-2-[4-(thiophen-3-ylmethoxy)-phenoxy]-pyridine 
• 758706-44-4 2-{4-[2-(3-fluoro-phenyl)-ethoxy]-phenoxy}-5-nitro-pyridine 
• 758706-47-7 2-(4-cyclohexylmethoxy-phenoxy)-5-nitro-pyridine 
• 758707-24-3 2-bromo-N-(6-{4-[(3-fluorobenzyl)oxy]phenoxy}pyridin-3-yl)propanamide 
• 845959-72-0 N-{6-[4-(3-fluoro-benzyloxy)-phenoxy]-pyridin-3-yl}-acrylamide 

Relevant academic research and scientific papers

Dihalopropenyl ether compounds,d and preparation and application thereof

The invention discloses dihalopropenyl ether compounds, preparation and application thereof. The compound is shown in a formula (I), wherein Q, R, R1, R2, R3, R4, R5, n, and v in the formula are defined in the description. The compounds shown in the formula (I) have insecticidal and/or bactericidal biological activity, and has very high activity particularly on pests such as mythimna separata and plutella xylostella.

Design, synthesis and insecticidal evaluation of aryloxy dihalopropene derivatives

Plutella xylostella (P. xylostella) is a highly migratory, cosmopolitan species and one of the most important pest of cruciferous crops worldwide. Pyridalyl as a novel class of insecticides has good efficacy against P. xylostella. On the basis of the commercial insecticide pyridalyl, a series of new aryloxy dihalopropene derivatives were designed and synthesized by using Intermediate Derivatization Methods. Their chemical structures were confirmed by 1H NMR, high-resolution mass spectrum (HRMS), and single-crystal X-ray diffraction analysis. The insecticidal activities of the new compounds against P. xylostella were evaluated. The results of bioassays indicated that most of the compounds showed moderate to high activities at the tested concentration, especially compounds 10e and 10g displayed more than 75% insecticidal activity against P. xylostella at 6.25 mg/L, while pyridalyl showed 50% insecticidal activity at the same concentration. The field trials result of the insecticidal activities showed that compound 10e as a 10% emulsifiable concentrate (EC) was effective in the control of P. xylostella at 75-150 g a.i./ha, and the mortality of P. xylostella for treatment with compound 10e at 75 g a.i./ha was equivalent to pyridalyl at 105 g a.i./ha.

Synthesis and structure-activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium-calcium exchanger

A series of 2-phenoxypyridine derivatives were prepared and evaluated for their inhibitory activity against the reverse and forward modes of the sodium-calcium exchanger (NCX). The structure-activity relationships of these compounds on the inhibitory activity for the sodium-calcium exchanger are discussed. The sodium-calcium exchanger (NCX) is known as the transporter that controls the concentration of Ca2+ in cardiac myocytes. In the setting of heart failure and myocardial ischemia-reperfusion, NCX underlies an arrhythmogenic transient inward current responsible for delayed after-depolarizations and nonreentrant initiation of ventricular tachycardia. NCX is an attractive target for treatment in heart failure and myocardial ischemia-reperfusion. We have designed and synthesized a series of phenoxypyridine derivatives, based on compound 3. These derivatives have been evaluated for their inhibitory activity against both the reverse and forward mode of NCX in CCL39 cells. We have discovered several novel potent NCX inhibitors (39q, 48k), which have a high selectivity for reverse NCX inhibitory activity.

Selective cleavage of aryl methyl ether moiety of aryloxy aryl methyl ether by 48% HBr/tetra-n-butylphosphonium bromide

Aryl methyl ether moiety in the molecule containing aryl aryl ether part along with aryl methyl ether part is selectively cleaved to give the desired substituted phenol in excellent yield by using 48% HBr in the presence of tetra-n-butylphosphonium bromid

Diethers of m- or p-hydroxyphenol

Diethers of m- or p-hydroxyphenol, as well as the monoethers, are prepared by reacting m- or p-tert.-butoxyphenol of the formula II STR1 with a halogen compound in the presence of a hydroxide, carbonate and/or bicarbonate of an alkali metal or alkaline ea