71985-41-6Relevant academic research and scientific papers
Novel synthesis of ynolates via the cleavage of ester dianions: α-bromo and α,α-dibromo esters as precursors
Shindo, Mitsuru,Sato, Yusuke,Shishido, Kozo
, p. 2411 - 2422 (1998)
Ynolates have been synthesized via the thermally-induced cleavage of ester dianions. The key intermediates, ester dianions, were generated from α-bromocarboxylic acid ester enolates via lithium halogen exchange. α,α-Dibromocarboxylic acid ester also gives lithium amide free ynolates by addition of tert-BuLi. The reactions of ynolates, generated by this novel and convenient method, with aldehydes to give β-lactons are discussed.
A synthesis of ynolates via the cleavage of ester dianions
Shindo, Mitsuru
, p. 4433 - 4436 (2007/10/03)
A new method for ynolate synthesis via the cleavage of ester dianions has been developed. The key intermediates, ester dianions, generated from α-bromocarboxylic acid ester enolates via lithium-halogen exchange turned out to be so labile that they were cleaved rapidly to give ynolates.
