71989-21-4 Usage
Description
FMOC-GLN-ONP is a chemical compound that consists of three components: FMOC (fluorenylmethyloxycarbonyl), GLN (glutamine), and ONP (o-nitrophenyl). It is a derivative of glutamine, a naturally occurring amino acid, and is commonly used in peptide synthesis. The ONP group is often used to facilitate the removal of FMOC during the peptide synthesis process. FMOC-GLN-ONP plays a crucial role in the protection and deprotection of amino acids in peptide synthesis and is an important tool in the field of biochemistry and molecular biology.
Uses
Used in Biochemistry and Molecular Biology:
FMOC-GLN-ONP is used as a protecting group for amino acids during peptide synthesis for the production of peptides for biological and pharmaceutical research.
Used in Pharmaceutical Research:
FMOC-GLN-ONP is used as a key component in the synthesis of peptides that have potential therapeutic applications in the development of new drugs and treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 71989-21-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,9,8 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 71989-21:
(7*7)+(6*1)+(5*9)+(4*8)+(3*9)+(2*2)+(1*1)=164
164 % 10 = 4
So 71989-21-4 is a valid CAS Registry Number.
71989-21-4Relevant articles and documents
Peptide Synthesis. Part 2. Procedures for Solid-phase Synthesis using Nα-fluorenylmethoxycarbonylamino-acids on Polyamide Supports. Synthesis of Substance P and of Acyl Carrier Protein 65-74 Decapeptide
Atherton, Eric,Logan, Christopher J.,Sheppard, Robert C.
, p. 538 - 546 (2007/10/02)
Use of base-labile Nα-9-fluorenylmethoxycarbonylamino-acids in combination with acid-labile t-butyl or p-alkoxybenzyl side-chain or carboxy-terminal (resin-linkage) protecting groups enables solid-phase peptide synthesis to be carried out under exceptionally mild reaction conditions.The repetitive and vigorous acidic treatments required in conventional synthesis are avoided.High-yield syntheses of a decapeptide and of an undecapeptide amide (Substance P) are described using this new combination of protecting groups on polyamide supports.