72030-16-1

Usage

Uses

Used in Pharmaceutical Industry:
(2Z)-2-phenyl-3-(thiophen-2-yl)prop-2-enenitrile is used as a building block in the development of new drugs due to its potential biological activities, such as anti-cancer, anti-bacterial, and anti-inflammatory properties. Its unique structure allows for the creation of various drug candidates with different therapeutic applications.
Used in Agrochemical Industry:
(2Z)-2-phenyl-3-(thiophen-2-yl)prop-2-enenitrile is used as a building block in the development of new pesticides. Its potential biological activities, such as anti-bacterial and anti-inflammatory properties, can be harnessed to create effective pest control agents, contributing to improved crop protection and yield.

Upstream product

• 636-72-6 2-thiophenemethanol 
• 140-29-4 phenylacetonitrile 
• 98-03-3 thiophene-2-carbaldehyde 

Relevant academic research and scientific papers

An aqueous phase synthesis of cyano substituted styrene compound method

The invention discloses a method for aqueous-phase synthesizing cyan-substituted styrene compounds. The cyan-substituted styrene compounds are synthesized by taking water as a solvent and taking benzyl cyanide and aromatic aldehyde as materials through noevenagel condensation reaction, wherein the aromatic aldehyde is selected from formula shown in the specification. According to the invention, the reaction is carried out at a room temperature; relative to other high-temperature reactions in the prior art, not only is yield improved, but also energy resources are saved, and therefore, the method is beneficial to low-carbon harmless green engineering. White spherical precipitates are generated after reaction and dehydration, and the white spherical precipitates are washed in water to neutral, and dried to obtain a target product; and besides, the method is simple in synthetic steps, easy for treatment and high in yield.

Dialkylamino cyclopentadienyl ruthenium(II) complex-catalyzed α-alkylation of arylacetonitriles with primary alcohols

Aminocyclopentadienyl ruthenium complexes, [(η5-C 5H4NMe2)Ru(PPh3)2(CH 3CN)]+BF4- and [(η5- C5H4NEt2)Ru(PPh3) 2(CH3CN)]+BF4-, are moderately active catalysts for α-alkylation of arylacetonitriles with primary alcohols; on the other hand, the analogous unsubstituted cyclopentadienyl ruthenium complex [(η5-C5H 5)Ru(PPh3)2(CH3CN)] +BF4- shows very low catalytic activity. On the basis of experimental results and theoretical calculations, rationalization for the much higher catalytic activity of the aminocyclopentadienyl complexes over that of the unsubstituted Cp complex is provided. In the catalytic systems with the former, it is possible to regenerate the active solvento complexes via protonation of the metal hydride intermediates and subsequent ligand substitution; this process is, however, very nonfacile in the catalytic system with the latter. The Royal Society of Chemistry 2010.