720682-99-5Relevant academic research and scientific papers
Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents
Li, Jin,Bertinato, Peter,Cheng, Hengmiao,Cole, Bridget M.,Bronk, Brian S.,Jaynes, Burton H.,Hickman, Anne,Haven, Michelle L.,Kolosko, Nicole L.,Barry, Chris J.,Manion, Tara B.
, p. 3039 - 3042 (2008/09/20)
We have successfully identified a number of novel MTP inhibitors with single digit nanomolar potency. Analogues 10aq and 10dq demonstrated in vivo efficacy in a murine gut retention assay.
Microsomal triglyceride transfer protein inhibitor
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Page/Page column 22, (2010/02/07)
The present invention provides inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion having Formula (I) which are useful for the treatment of obesity and related diseases, as well as prevention and treatment of atherosclerosis and its clinical sequelae, for lowering serum lipids, and in the prevention and treatment of related diseases. The invention further relates to pharmaceutical compositions comprising the compounds of the present invention and to methods of treating obesity, atherosclerosis, and related diseases and/or conditions with the compounds of the present invention, either alone or in combination with other medicaments, including lipid-lowering agents.
