720692-76-2

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 264264-28-0 1,1-dimethylethyl-7-{[(trifluoromethyl)sulfonyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 

Downstream Products

• 720692-77-3 (3-{[(1,1-dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)boronic acid 
• 865111-77-9 1,1-dimethylethyl 7-(4-cyanophenyl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 
• 865111-81-5 1,1-dimethylethyl 7-{4-[2-(methylamino)-2-oxoethyl]phenyl}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 
• 1258440-66-2 1,1-dimethylethyl 7-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 
• 1258440-42-4 1,1-dimethylethyl 7-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 
• 1258440-68-4 1,1-dimethylethyl 7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 
• 1258440-10-6 2-[(1-methylethyl)oxy]-5-[5-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3,4-thiadiazol-2-yl]benzonitrile mono-trifluoroacetate 
• 1258856-66-4 5-{5-[3-(2,2-dimethyl-1,3-dioxan-5-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,3,4-thiadiazol-2-yl}-2-[(1-methylethyl)oxy]benzonitrile 
• 1258856-67-5 5-{5-[3-(bromoacetyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,3,4-thiadiazol-2-yl}-2-[(1-methylethyl)oxy]benzonitrile 
• 1258854-36-2 5-{5-[3-(2-hydroxyethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,3,4-thiadiazol-2-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride 
• 1258852-29-7 5-{5-[3-(3-hydroxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,3,4-thiadiazol-2-yl}-2-[(1-methylethyl)oxy]benzonitrile 
• 1258852-30-0 2-[(1-methylethyl)oxy]-5-(5-{3-[2-(methyloxy)ethyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride 
• 720692-80-8 1,1-dimethylethyl 7-{[4-[(methylamino)carbonyl]-2-(methyloxy)phenyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 
• 1398697-84-1 1,1-dimethylethyl 7-{5-acetyl-2-[(2-pyrazinylmethyl)oxy]phenyl}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 

Relevant academic research and scientific papers

PYRIDINYL- AND PYRAZINYL -METHYLOXY - ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK)

A compound of formula (I) or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammato

NOVEL COMPOUNDS

A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammat

THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Thiazole or thiadizaloe derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated

S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING

The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

BENZAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS

The present invention relates to novel benzazepine derivatives of formula (I); wherein: R1 represents -C3-7 cycloalkyl optionally substituted by C1-3 alkyl; R2 represents -aryl, -heterocyclyl, heteroaryl, -aryl-X-C3-8 cycloalkyl, -aryl-X-aryl, -aryl-X-heteroaryl, -aryl-X-heterocyclyl, -heteroaryl-X-C3-8 cycloalkyl, -heteroaryl-X-aryl, -heteroaryl-X-heteroaryl, -heteroaryl-X-heterocyclyl, -heterocyclyl-X-C3-8 cycloalkyl, -heterocyclyl-X-aryl, -heterocyclyl-X-heteroaryl or -heterocyclyl-X-heterocyclyl; X represents a bond , O, CO, -CH2O-, -COCH2-, -COCH2O-, -CONR2b-, -COCH2 NR2bCO-, -CSNH-, SO2, -SO2C1-3 alkyl-, -SO2C2-3 alkenyl-, -COC2-3 alkenyl-, -CO-C(R2a)(R2b)- or -CO- C(R2a)(R2b)CH2-; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

BENZO ‘ D!AZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS

The present invention relates to benzazepine derivatives of formula ( I ) wherein: R1 represents -C3-7 cycloalkyl optionally substituted by C1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.