720720-60-5

Basic information

• Product Name: 4-(3-oxoMorpholino)benzoic acid
• Synonyms: 4-(3-oxoMorpholino)benzoic acid;Benzoic acid, 4-(3-oxo-4-Morpholinyl)-
• CAS NO: 720720-60-5
• Molecular Formula: C₁₁H₁₁NO₄
• Molecular Weight: 221.20934
• Mol File: 720720-60-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(3-oxoMorpholino)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-oxoMorpholino)benzoic acid(720720-60-5)
• EPA Substance Registry System: 4-(3-oxoMorpholino)benzoic acid(720720-60-5)

Safety Data

• Hazardous Substances Data: 720720-60-5(Hazardous Substances Data)

Upstream product

• 766556-56-3 ethyl 4-(3-oxomorpholino)benzoate 
• 23676-05-3 4-morpholin-4-yl-benzoic acid methyl ester 
• 7470-38-4 4-morpholin-4-yl-benzoic acid 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 19614-15-4 4-(morpholin-4-yl)benzoic acid ethyl ester 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 1057647-23-0 N-{2-[4-(3-oxomorpholin-4-yl)benzoylamino]benzyl}-5-chlorothiophene-2-carboxamide 

Relevant articles and documents

Design, synthesis and biological evaluation of anthranilamide derivatives as potential factor Xa (fXa) inhibitors

Factor Xa (fXa) is a crucial player in various thromboembolic disorders. Inhibition of fXa can provide safe and effective antithrombotic effects. In this study, a series of anthranilamide compounds were designed by utilizing structure-based design strategies. Optimization at P1 and P4 groups led to the discovery of compound 16g: a highly potent, selective fXa inhibitor with pronounced in vitro anticoagulant activity. Moreover, 16g also displayed excellent in vivo antithrombotic activity in the rat venous thrombosis (VT) and arteriovenous shunt (AV-SHUNT) models. The bleeding risk evaluation showed that 16g had a safer profile than that of betrixaban at 1 mg/kg and 5 mg/kg dose. Additionally, 16g also exhibited satisfactory PK profiles. Eventually, 16g was selected to investigate its effect on hypoxia-reoxygenation- induced H9C2 cell viability. MTT results showed that H9C2 cell viability can be remarkably alleviated by 16g.

SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa

In the search of Factor Xa (FXa) inhibitors structurally different from the pyrazole-based series, we identified a viable series of enantiopure cis-(1R,2S)-cycloalkyldiamine derivatives as potent and selective inhibitors of FXa. Among them, cyclohexyldiam

LACTAM-CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS

The present application describes lactam-containing cyclic diamines and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein M is a non-aromatic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trysin-like serine proteases, specifically factor Xa.