72076-59-6

Basic information

• Product Name: Ethanone, 1-(4-methylphenyl)-2-(2-pyridinyl)-
• CAS NO: 72076-59-6
• Molecular Formula: C14H13NO
• Molecular Weight: 211.263
• Mol File: 72076-59-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-methylphenyl)-2-(2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-methylphenyl)-2-(2-pyridinyl)-(72076-59-6)
• EPA Substance Registry System: Ethanone, 1-(4-methylphenyl)-2-(2-pyridinyl)-(72076-59-6)

Safety Data

• Hazardous Substances Data: 72076-59-6(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(4-methylphenyl)-2-(2-pyridinyl)- is a chemical compound with the molecular formula C16H15NO. It is a ketone that contains a 4-methylphenyl group and a 2-pyridinyl group. This chemical is often used in organic synthesis and pharmaceutical research. It may have potential applications in the development of new drugs or in the production of other organic compounds. Additionally, it may also have various industrial uses due to its unique chemical properties.

Upstream product

• 1749-29-7 2-pyridylmethyllithium 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 109-06-8 α-picoline 
• 104-85-8 para-methylbenzonitrile 
• 74115-44-9 (Z)-2-[2]pyridyl-1-p-tolyl-vinyl alcohol 
• 17881-80-0 (2-picolyl)trimethylsilane 

Downstream Products

• 92360-23-1 (C₅H₄NCH₂COC₆H₄CH₃)2Ni(NCS)2 
• 92360-20-8 C₅H₄NCH₂COC₆H₄CH₃Ni(NCS)2 
• 92360-03-7 (C₅H₄NCH₂COC₆H₄CH₃Co(NCS)2) 

Relevant articles and documents

Tautomer-selective derivatives of enolate, ketone and enaminone by addition reaction of picolyl-type anions with nitriles

We describe an efficient for the synthesis of compounds of tautomeric β-pyridyl/quinolyl-enol, -ketone, -enaminone, which were finally characterized by standard methods like NMR, IR or SCXRD. The addition reaction of lithiated intermediates of picoline, 2-ethylpyridine and 2-methylquinoline, respectively, with nitriles followed by acid hydrolysis afforded the corresponding tautomeric compounds of enol, ketone and emaminone. Interestingly, treatment of 2-methylpyridine or 2-ethylpyridine with nitriles, respectively, yielded mostly β-pyridyl ketone and enol tautomers without enaminones, while 2-methylquinoline with nitriles gave β-quinolyl ketone and enaminone tautomers without enols. The reaction of 2-benzylpyridine with nitriles was not available under the same conditions.

Chiroptical, Structural and Catalytic Properties of S-α-Methyl-benzylamines and their Rh(I) and Cu(I) Complexes

S-α-Methyl-benzylamines 15-21 and their Rh(I) complexes 22-28 are prepared and their chiroptical and conformational properties are studied.Free ligands are present as enamines in the solution and in the solid state, but are bound to Rh(I) in the imine form.The CD spectra confirm that complexation of 15-21 induces both structural change and strong conformational perturbations.The molecular structures in the crystal are reported for the chiral 1,5-bisnitrogen ligand 18, and its Rh perchlorate complex 25.The absolute conformation of the chromophore in 18 inverts on binding to Rh(I) in 25.The value of the torsional angle about C10-C9-C16-C21 bond (- 69.7 deg) in 18, which defines the twisted stilbene-like chromophore, turns for 25 into 75.0 deg.Chiral (S)-(-)-methylbenzyl subunit in 18 has a C1-N1-C9-C10 torsional angle of 175.2 deg, whereas on binding to Rh(I) in 25 this angle changes to -178.4 deg.The absolute conformation around the styrene-like arrangement of the bonds in 15-21 can be deduced from the strong positive Cotton effect at ca. 350 nm.Cyclopropanation of styrene with ethyl diazoacetate, in the presence of in situ generated Cu(I) complexes of chiral 1,5-bidentate ligands 15-21, yielded cis/trans 2-phenylcyclopropan-1-carboxylic acid ethylesters with 5-21percent e.e.Though generally low, the enantioselectivity was somewhat higher for ortho-(16-18) than for para-(19-21) substituted phenyl derivatives.