72083-70-6

Upstream product

• 37670-50-1 ethyl 5-methyl-1-methylpyrrole-2-carboxylate 
• 74-88-4 methyl iodide 
• 3284-51-3 ethyl 5-methyl-1H-pyrrole-2-carboxylate 
• 183268-72-6 2,2,2-trichloro-1-(5-methyl-1H-pyrrol-2-yl)ethan-1-one 
• 25907-27-1 Ethyl 5-methyl-4-nitropyrrole-2-carboxylate 
• 636-41-9 2-methyl-1H-pyrrole 

Downstream Products

• 72795-81-4 4-nitro-5-methyl-1-methylpyrrole-2-carboxylic acid 
• 72083-72-8 1,2-Dimethyl-3-nitropyrrole 
• 13138-78-8 1-methyl-4-nitro-pyrrol-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and nucleophilic properties of 1,2 -dialkyl-3-nitropyrroles and 1,5-dialkyl-4-nitropyrrole-2-carboxylic acid derivatives

1,2-Dialkyl-3-nitropyrroles 1 are versatile synthetic tools for obtaining substituted pyrrolidines or fused ring heterocycles such as pyrrolopyridines, pyrrolopyrimidines or pyrroloazepines. We have established a method for obtaining compounds related to structure 1 and studied the reactivity as a nucleophile of the benzylic type moiety in the alkyl residue bound to position 2.

PREPARATIVE ASPECTS OF THE NITRATION OF 1-METHYLPYRROLE DERIVATIVES. 13C NMR OF SOME NITROPYRROLES.

The nitration of 1-methylpyrrole and 1,2-dimethylpyrrole was studied and the products were characterized. It was found that the nitration of ethyl 1-methylpyrrole-2-carboxylate depends on the reaction conditions. **1**3C parameters have been determined for several 1-methyl substituted pyrrole- and nitropyrrole derivatives and the relationship between the observed and predicted **1**3C shifts for aromatic carbons is briefly discussed. It has been found that the determination of the direct **1**3C-**1H coupling constants in the pyrrole ring constitutes a useful tool for distinguishing alpha - and beta -positions.