72087-94-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(morpholin-4-yldisulfanyl)-1,3-diphenylpropane-1,3-dione is used as a medication for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. It serves as a neuroprotective agent, slowing the progression of the disease and extending the survival of patients by inhibiting the release of glutamate, which can be toxic to nerve cells in high concentrations.
Used in Neurological Research:
2-(morpholin-4-yldisulfanyl)-1,3-diphenylpropane-1,3-dione is used as a research tool for investigating its potential therapeutic effects in other neurological conditions such as Parkinson's disease, Alzheimer's disease, and spinal cord injury. Its neuroprotective properties make it a promising candidate for further studies to understand its mechanisms and explore its potential uses in these conditions.

Upstream product

• 72087-87-7 dibenzoylchlormethansulfenylchlorid 
• 110-91-8 morpholine 
• 72087-90-2 Acetyl-dibenzoylchloromethyl-disulfide 

Relevant academic research and scientific papers

Dithiirane or Thiosulfine Intermediates in the Reaction of Acetyl Diaroylchloromethyl Disulfides with Secondary Amines? [1, 2]

Since 1979, Senning's acetyl dibenzoylchloromethyl disulfide has been known as one of the first thiosulfine/dithiirane precursors. Its reactions with an excess of morpholine fulfill three advantageous conditions at once: thiosulfine or dithiirane species

APPROACHES TO THE LIBERATION OF THIOSULFINES

In 1979 A.Senning found a series of reactions that involve probably thiosulfines of thiocarbonyl S-sulfides.Now, disulfide 5a was chosen for a re-examination, as no rearrangements seem to be involved.F, Cl, Br, CH3, and CH3O are used to change the electro

STUDIES OF DITHIIRANES AND THIOSULFINES AS REACTIVE INTERMEDIATES

Indirect, but compelling evidence for the intermediacy of dithiiranes 1 and thiosulfines 2 has been found by us and is also provided by literature data.The intriguing dithiirane -> dithioester rearrangement as well as most of the interrelations and conversions postulated in Scheme 1 have been demonstrated experimentally.In a number of cases acetyl α-chloroalkyl disulfides 16 (X=Cl, Y=COCH3) are useful starting materials for the synthesis of thioamides such as 40.