72093-42-6

Usage

Uses

Used in Pharmaceutical Research:
1,1'-Biphenyl, 3-fluoro-4'-methylis used as a research compound for studying its properties and potential applications in the development of new pharmaceuticals. Its unique structure with a fluorine atom and a methyl group may offer specific advantages in drug design and synthesis.
Used in Materials Science:
1,1'-Biphenyl, 3-fluoro-4'-methylmay have potential applications in materials science, where its unique chemical structure could contribute to the development of new materials with specific properties. Further research is needed to explore its potential in this field.
Used in Agricultural Research:
1,1'-Biphenyl, 3-fluoro-4'-methylis also being studied for its potential applications in agriculture. Its properties may be useful in the development of new agrochemicals or in improving existing ones. However, more research is required to fully understand its potential in this area.

Upstream product

• 106-39-8 bromochlorobenzene 
• 1073-06-9 3-fluorobromobenzene 
• 462-06-6 fluorobenzene 
• 106-38-7 para-bromotoluene 
• 71-43-2 benzene 

Relevant academic research and scientific papers

Assessment of the intermediacy of arylpalladium carboxylate complexes in the direct arylation of benzene: Evidence for C-H bond cleavage by "ligandless" species

Palladium-catalyzed direct arylations of benzene have been proposed to occur by the generation of a phosphine-ligated arylpalladium pivalate complex LPd(Ar)(OPiv) and reaction of this complex with benzene. We have isolated an example of the proposed intermediate and evaluated whether this complex does react with benzene to form the biaryl products of direct arylation. In contrast to the proposed mechanism, no biaryl product was formed from cleavage of the benzene C-H bond by LPd(Ar)(OPiv). However, reactions of LPd(Ar)(OPiv) with benzene and additives that displace or consume the phosphine ligand formed the arylated products in good yield, suggesting that a "ligandless" arylpalladium(II) carboxylate complex undergoes the C-H cleavage step. Consistent with this conclusion, we found that reactions catalyzed by Pd(OAc)2 without a ligand occur faster than, and with comparable selectivities to, reactions catalyzed by Pd(OAc)2 and a phosphine ligand.

Structure-reactivity relationships in negishi cross-coupling reactions

Competition experiments have been performed to determine the relative reactivities of substituted bromobenzenes and of different arylzinc reagents in the [Pd(PPh3)4]-catalyzed Negishi cross-coupling reaction in THF at 25 °C. The crosscoupling reactions are accelerated by electron acceptors in the bromobenzenes, the effect of which increases in the order ortho a larger effect than substituent variations in the arylzinc halides (ρ = -0.98).