72109-63-8

Upstream product

• 106-44-5 p-cresol 
• 6296-63-5 4-bromo-2,6-bis(hydroxymethyl)phenol 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 51775-05-4 4-bromo-2,6-bis-(2-hydroxy-3-hydroxymethyl-5-methyl-benzyl)-phenol 

Relevant academic research and scientific papers

Facile synthesis of calix[5]arenes with three different upper rim substituents

Four calix[5]arenes, which have three different substituents at the upper rim of calix, are synthesized by the '3 + 2' fragmentation condensation reaction. An equimolar mixture of p-substituted phenol trimer (BCB) and 2,2'-bishydroxymethyl p-substituted p

Synthesis of Monofunctionalized Calix[5]arenes

Seven OH-free and O -permethylated monofunctionalized calix[5]arenes carrying either additional methyl or tert -butyl groups are prepared following fragment condensation protocols. This strategy proves to be superior to previous approaches. Calix[5]arenes with free OH groups all adopt a cone conformation stabilized by a seam of hydrogen bonds at the lower rim. Post-condensation modifications, i.e., methylation of phenolic OH groups or functional group interconversions can also be achieved. Bulky tert -butyl groups are also found to stabilize the cone conformations of O -methylated compounds. These compounds offer versatile functional groups that make these concave molecules interesting building blocks for the synthesis of more sophisticated molecular architectures.