7211-54-3

Basic information

• Product Name: (3-mercaptopropyl)ammonium chloride
• Synonyms: 3-Amino-1-propanethiolHCl;1-Propanethiol, 3-aMino-, hydrochloride;3-Mercaptopropan-1-aMiniuM chloride;3-aMinopropane-1-thiolHCL;Homocysteamine hydrochloride;3-Mercaptopropylamine hydrochloride;3-Amino-1-propanethiol hydrochloride technical grade;3-aminopropane-1-thiol hydrochloride
• CAS NO: 7211-54-3
• Molecular Formula: C₃H₁₀NS*Cl
• Molecular Weight: 127.6362
• EINECS: 230-593-3
• Mol File: 7211-54-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 79-80℃
• Boiling Point: 151.4°C at 760 mmHg
• Flash Point: 45.4°C
• Appearance: /
• Vapor Pressure: 3.67mmHg at 25°C
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: (3-mercaptopropyl)ammonium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (3-mercaptopropyl)ammonium chloride(7211-54-3)
• EPA Substance Registry System: (3-mercaptopropyl)ammonium chloride(7211-54-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• RIDADR: UN 3335
• WGK Germany: 3
• Hazardous Substances Data: 7211-54-3(Hazardous Substances Data)

Usage

Uses

APT can be used to form a plasmonic tunneling gap through coulomb blockage which can be potentially used in high-speed switching devices. It can also form a SAM on gold nanorods(AuNR) for controlled spacing and photon absorption in photovoltaic and other photo-sensors based devices.

General Description

3-Amino-1-propanethiol hydrochloride (APT) is an aminoalkylthiol that forms a self-assembled monolayer (SAM) of amine terminated alkanethiol. It can be used to form a spacer layer that provides a gap between the metal surface and nanoparticles.

InChI:InChI=1/C3H9NS.ClH/c4-2-1-3-5;/h5H,1-4H2;1H

Upstream product

• 15047-09-3 2-Methyl-4,6-dihydro-4H-[1,3]thiazine 
• 5554-48-3 Tetrahydro-1,3-thiazin-2-thion 
• 463-22-9 homocystamine 
• 114326-11-3 S-(3-((tert-butoxycarbonyl)amino)propyl) ethanethioate 
• 462-47-5 mercapto-3 propylamine 

Downstream Products

• 79128-45-3 2-p-Tolyl-[1,3]thiazinane; hydrochloride 
• 79128-43-1 2-(4'-fluorophenyl)-1,3-perhydrothiazine hydrochloride 
• 79128-44-2 2-(4-Chloro-phenyl)-[1,3]thiazinane; hydrochloride 
• 79128-36-2 ethyl-2 perhydrothiazine-1,3 chlorhydrate 
• 79128-48-6 2-o-Tolyl-[1,3]thiazinane; hydrochloride 
• 98156-91-3 N-(3-Mercaptopropyl)benzenesulfonamide 
• 67755-06-0 3,4-dihydro-2H-[1,3]thiazino[3,2-b]isoquinolin-6-one 
• 79137-08-9 2-(3,4-Dichloro-phenyl)-[1,3]thiazinane; hydrochloride 
• 79128-37-3 propyl-2 perhydrothiazine-1,3 chlorhydrate 
• 79128-35-1 methyl-2 perhydrothiazine-1,3 chlorhydrate 
• 79128-42-0 phenyl-2 perhydrothiazine-1,3 chlorhydrate 
• 1259978-05-6 Kb-NB₁₆₅-89 

Relevant articles and documents

Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors

Selective inhibition of KDAC isoforms while maintaining potency remains a challenge. Using the largazole macrocyclic depsipeptide structure as a starting point for developing new KDACIs with increased selectivity, a combination of four different simplified largazole analogue (SLA) scaffolds with diverse zinc-binding groups (for a total of 60 compounds) were designed, synthesized, and evaluated against class I KDACs 1, 3, and 8, and class II KDAC6. Experimental evidence as well as molecular docking poses converged to establish the cyclic tetrapeptides (CTPs) as the primary determinant of both potency and selectivity by influencing the correct alignment of the zinc-binding group in the KDAC active site, providing a further basis for developing new KDACIs of higher isoform selectivity and potency.

PROTEIN KINASE D INHIBITORS

Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription, and protein trafficking. Accordingly, pharmaceutically acceptable compositions of the inventive compounds are candidate therapeutics for pathological conditions conditioned by changes in PKD activity.

Reversible inactivation of bovine plasma amine oxidase by cysteamine and related analogs

Cysteamine (1) was reported many years ago to reversibly inhibit lentil seedling amine oxidase, through the formation of a complex with thioacetaldehyde, the turnover product of 1. Herein, cysteamine (1) and its analogs 2-(methylamino)ethanethiol (3) and 3-aminopropanethiol (6) were found to be reversible inhibitors of bovine plasma amine oxidase (BPAO), but 2-(methylthio)ethylamine (7) was determined to be a weak irreversible inhibitor of BPAO. Based on our results, indicating the necessity of a sulfhydryl-amine for reversible inactivation of BPAO, the failure of inhibited BPAO to recover activity after gel filtration, the first-order kinetics of activity recovery upon dialysis, and 2,4,6-trihydroxyphenylalanine quinine (TPQ) cofactor transformation which indicated from the results of phenylhydrazine titration and substrate protection, we propose a mechanism for the reversible inactivation of BPAO by 1 involving the formation of a cofactor adduct, thiazolidine, between BPAO and 1.