462-47-5

Usage

Uses

Used in Organic Synthesis and Biochemistry:
3-aminopropanethiol is used as a building block for the synthesis of various compounds, including pharmaceuticals and agricultural chemicals. Its ability to form stable covalent bonds with other molecules makes it a valuable component in the creation of new and effective drugs and agrochemicals.
Used in Petroleum Industry:
3-aminopropanethiol is used as a corrosion inhibitor in petroleum products. Its presence in these products helps to prevent the corrosion of pipelines and storage tanks, thereby extending their service life and reducing maintenance costs.
Used in Rubber Chemicals Production:
3-aminopropanethiol is used as a component in the production of rubber chemicals. It contributes to the improvement of rubber properties, such as elasticity, durability, and resistance to environmental factors, making it an essential ingredient in the rubber industry.
Used in Herbicide Production:
3-aminopropanethiol is used in the production of herbicides, which are essential for controlling unwanted plant growth in agricultural fields. Its incorporation into these chemicals enhances their effectiveness in targeting specific weeds without harming the desired crops.
Used in Medical Applications:
3-aminopropanethiol is used as a treatment for radiation-induced bone marrow suppression. Its ability to stimulate the production of blood cells helps to alleviate the side effects of radiation therapy, improving the quality of life for cancer patients.
Additionally, 3-aminopropanethiol is used as a drug for the treatment of acute leukemia. Its potential to target and eliminate cancerous cells makes it a promising therapeutic agent in the field of oncology.

InChI:InChI=1/C3H9NS/c4-2-1-3-5/h5H,1-4H2

Upstream product

• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 408341-23-1 dithiocarbonic acid O-ethyl ester-S-(3-phthalimido-propyl ester) 
• 107-11-9 1-amino-2-propene 
• 5554-48-3 Tetrahydro-1,3-thiazin-2-thion 
• 14753-26-5 3-chloropropan-1-amine 
• 6276-54-6 3-chloropropylamine hydrochloride 
• 10017-11-5 allylammonium chloride 
• 287-27-4 trimethylene sulphide 
• 64-17-5 ethanol 
• 7664-41-7 ammonia 
• 7647-01-0 hydrogenchloride 
• 39801-32-6 2-(3-mercaptopropyl)isoindoline-1,3-dione 
• 7320-57-2 S-aminopropylisothiourea 
• 7732-18-5 water 

Downstream Products

• 543-71-5 perhydrothiazine-1,3 
• 180-92-7 1-thia-5-aza-spiro[5.5]undecane 
• 92333-46-5 2--1.3.2-azathiaphosphorinan-oxyd-(2) 
• 25478-53-9 5,6-dihydro-2-benzyl-4H-1,3-thiazine 
• 46739-63-3 2-(4-methoxy-phenethyl)-5,6-dihydro-4H-[1,3]thiazine 
• 802597-89-3 2-(2-m-tolyl-ethyl)-5,6-dihydro-4H-[1,3]thiazine 
• 46457-51-6 2-(3-fluoro-phenethyl)-5,6-dihydro-4H-[1,3]thiazine 
• 46459-22-7 2-(4-fluoro-phenethyl)-5,6-dihydro-4H-[1,3]thiazine 
• 3592-66-3 phenyl-2 perhydrothiazine-1,3 
• 25468-89-7 2-(3-phenyl-propyl)-5,6-dihydro-4H-[1,3]thiazine 
• 70818-07-4 8-phenyl-3,4-dihydro-2H-pyrido[2,1-b][1,3]thiazin-6-one 
• 6671-31-4 3,4-dihydro-2H-<1,3>thiazino<2,3-a>isoindol-6(10bH)-one 
• 71090-96-5 tetrahydro-2-(nitromethylene)-1,3thiazine 
• 7211-54-3 homocysteamine hydrochloride 

Relevant academic research and scientific papers

Integrating amino groups within conjugated microporous polymers by versatile thiol-yne coupling for light-driven hydrogen evolution

Conjugated microporous polymers (CMPs) are emerging as promising catalysts for photocatalytic hydrogen evolution, but hydrophobic surfaces and less active site exposure severely limit their efficiency. Herein, we contribute an effective and versatile strategy to functionalize CMPs with abundant amino groups via the radical thiol-yne reaction. As a result, the modified CMPs retain their light absorption ability and morphology, and the better water compatibility along with increased active site exposure may accelerate subsequent proton reduction under visible light irradiation (λ > 420 nm). The hydrogen evolution rate (HER) and apparent quantum yield (AQY) at 420 nm of modified CMPs were increased up to 27.2 times and 47.1 times in comparison to those of original CMPs. Photocatalytic H2 evolution activity evaluation of BBT-SC2CH3, BBT-SC2N(CH3)2 and SC2NHAc in which amino groups were replaced with methyl, dimethyl amino or N-acetyl groups revealed the crucial role of nitrogen, and the aliphatic chain length between sulfur and nitrogen also proved important. Therefore, this protocol provides good opportunities for designing advanced CMPs and expands their application as photocatalysts for energy conversion.

NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF

The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.

Convenient synthesis of various substituted homotaurines from alk-2-enamides

Various substituted homotaurines (=3-aminopropane-1-sulfonic acids) 6 were readily synthesized in satisfactory to good yields via the Michael addition of thioacetic acid to alk-2-enamides 3 (→4), followed by LiAlH4 reduction (→5) and performic acid oxidation (Scheme 1). The configuration of 'anti'-disubstituted homotaurine 'anti'-6h was deduced from the 3-(acetylthio)alkanamide (=S-(3-amino-1,2-dimethyl-3-oxopropyl) ethanethioate)'anti'-4h formed in the Michael addition, which was identified via the Karplus equation analysis, and confirmed by X-ray diffraction analysis. The current route is an efficient method to synthesize diverse substituted homotaurines, including 1-, 2-, and N-monosubstituted, as well as 1,2-, 1,N-, 2,N-, and N,N-disubstituted homotaurines (Table). Copyright

Synthesis of homotaurine and 1-substituted homotaurines from α,β-unsaturated nitriles

Homotaurine and a series of 1-substituted homotaurines were readily synthesized in satisfactory to good yields via the Michael addition of thioacetic acid to aliphatic and aromatic α,β-unsaturated nitriles followed by lithium aluminum hydride mediated reduction and performic acid oxidation. The synthesis of 1,1-disubstituted homotaurines was attempted with β,β-disubstituted acrylonitriles as starting materials but failed due to steric hindrance. The current process is an efficient method for the synthesis of 1-substituted homotaurines. Georg Thieme Verlag Stuttgart New York.

Reversible inactivation of bovine plasma amine oxidase by cysteamine and related analogs

Cysteamine (1) was reported many years ago to reversibly inhibit lentil seedling amine oxidase, through the formation of a complex with thioacetaldehyde, the turnover product of 1. Herein, cysteamine (1) and its analogs 2-(methylamino)ethanethiol (3) and 3-aminopropanethiol (6) were found to be reversible inhibitors of bovine plasma amine oxidase (BPAO), but 2-(methylthio)ethylamine (7) was determined to be a weak irreversible inhibitor of BPAO. Based on our results, indicating the necessity of a sulfhydryl-amine for reversible inactivation of BPAO, the failure of inhibited BPAO to recover activity after gel filtration, the first-order kinetics of activity recovery upon dialysis, and 2,4,6-trihydroxyphenylalanine quinine (TPQ) cofactor transformation which indicated from the results of phenylhydrazine titration and substrate protection, we propose a mechanism for the reversible inactivation of BPAO by 1 involving the formation of a cofactor adduct, thiazolidine, between BPAO and 1.

Targeted Nanostructures for Cellular Imaging

Compositions and methods related to targeted carbon nanostructures. More particularly, targeted carbon nanostructures comprising: a Cn, a cross-linker, and a targeting agent, wherein Cn refers to a fullerene moiety or nanotube comprising n carbon atoms. One example of a method may involve a method for imaging comprising: contacting a targeted carbon nanostructure and a cell; allowing the cell to internalize the carbon nanostructure; and detecting the presence of internalized carbon nanostructures.

Cyclic amino-thioacetal amides, a process for the preparation thereof and pharmaceutical compositions

Cyclic amino-thioacetal amides of formula I STR1 wherein X is O, S, p is 1 or 2, R and R1 are optionally esterified hydrogen or carboxy, A is a single bond, methylene or ethylene, m is zero or 1, n is an integer 1 to 7 and y is a imidazole or β-pyridylmethyl residue. Compounds I have valuable therapeutic properties.

Studies on Amino Acid Derivatives. Part 7. General Method for the Synthesis of Penam and Cepham and Their Substituted Derivatives

Penam (7-oxo-4-thia-1-azabicycloheptane), a basic skeleton of penicillin-type β-lactams, has been synthesized as a stable compound from thiazolidinylacetic acid.The key step in this synthesis is the formation of the β-lactam ring by Mukaiyama-Ohno's procedure.Three methods are developed for the synthesis of thiazolidinylacetic acid from cysteamine by reactions with ethyl propiolate, ethyl ethoxycarbonylacetimidate, or t-butyl formylacetate.Using appropriate derivatives of the latter compounds, 5-, 6-, and 5,6-substituted derivatives of penam are also synthesized.The yields of the bicyclic β-lactams are shown to be strongly dependent upon the pattern of substituents on the thiazolidinylacetic acid.The synthesis of cephams using homocysteamine is also described.

Heterocyclic carbothioamides

2-Substituted-N-(3-substituted phenyl)thiazolidine-, tetrahydro-2H-1,3-thiazine-, and benzothiazoline-3-carbothioamides, useful as insecticides.