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ZM 130352, also known as 2-(4-chlorophenyl)-N-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetamide, is a potent and selective inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme plays a crucial role in the mitochondrial synthesis of pyrimidine nucleotides, which are essential for DNA replication and cell proliferation. By inhibiting DHODH, ZM 130352 disrupts the pyrimidine synthesis pathway, leading to a reduction in cellular proliferation and is being investigated for its potential use in cancer treatment and other therapeutic applications.

72114-92-2

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72114-92-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 72114-92-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,1,1 and 4 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 72114-92:
(7*7)+(6*2)+(5*1)+(4*1)+(3*4)+(2*9)+(1*2)=102
102 % 10 = 2
So 72114-92-2 is a valid CAS Registry Number.

72114-92-2Downstream Products

72114-92-2Relevant academic research and scientific papers

Non-steroidal antiandrogens. Design of novel compounds based on an infrared study of the dominant conformation and hydrogen-bonding properties of a series of anilide antiandrogens

Morris,Hughes,Glen,Taylor

, p. 447 - 455 (2007/10/02)

Antiandrogenic activity is observed in anilides containing a tertiary hydroxyl group, and these compounds are used to define a pharmacophore in terms of their physicochemical properties. Infrared spectroscopy shows that these anilides exist in a single co

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