72120-54-8

Usage

Uses

Used in Pharmaceutical Industry:
Tetrahydro-1,3(2H)-pyridazinedicarboxylic acid 1-(phenylmethyl) ester is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical structure allows for the development of new compounds with potential therapeutic applications.
Used in Chemical Research:
Tetrahydro-1,3(2H)-pyridazinedicarboxylic acid 1-(phenylmethyl) ester is used as a research compound in the field of organic chemistry. Its complex structure provides opportunities for studying the properties and reactions of pyridazines and carboxylic acid esters, contributing to the advancement of chemical knowledge.
Used in Material Science:
Tetrahydro-1,3(2H)-pyridazinedicarboxylic acid 1-(phenylmethyl) ester is used as a building block in the development of new materials. Its unique chemical properties can be exploited to create novel materials with specific characteristics, such as improved stability or reactivity, for various applications in material science.

Upstream product

• 501-53-1 benzyl chloroformate 
• 62221-99-2 hexahydro-1,2-dioxo-2-phenyl-s-triazolo<1,2-a>pyridazine-5-carboxylic acid 
• 626-99-3 1,3-butadiene-1-carboxylic acid 
• 1219380-72-9 N,N'-di-tert-butoxycarbonylpiperazic acid 

Downstream Products

• 81383-51-9 1-benzyl 3-tert.butyl 2-(2-ethoxycarbonyl-2-methylacetyl)hexahydropyridazine-1,3-dicarboxylate 
• 81383-49-5 t-butyl 1-benzyloxycarbonylhexahydropyridazine-3-carboxylate 

Relevant academic research and scientific papers

Piperazic acid derivatives inhibit Gli1 in Hedgehog signaling pathway

Piperazic acid, a non-proteinogenic amino acid, found in complex secondary metabolites and peptide natural substances, has shown down regulation of Gli1 expression in Hedgehog signaling pathway in cell based assays. Further structure activity relationship

IMPROVED PROCESS FOR THE MANUFACTURE OF 1,2-DISUBSTITUTED HEXAHYDROPYRIDAZINE-3-CARBOXYLIC ACIDS AND ESTERS THEREOF

The invention relates to an improved process for the manufacture of 1,2-disubstituted hexahydro-pyridazine-3-carboxylic acids and esters thereof by reacting N,N’-disubstituted hydrazine with 2,5-dihalogenated valeric acids and thereof by means of phase transfer catalysis. Said pyridazine carboxylic acids and esters thereof can be used as intermediates for the production of pharmaceutical products

Process for preparing hexahydropyridazine-3-carboxylic acid derivatives

According to the process of the invention, the hexahydropyridazine-3-carboxylic acid derivatives are prepared by reacting a compound of formula (II) with a compound of formula (III) in the presence of a base with a pK of greater than or equal to 8.5, in a ketone organic solvent, to obtain an intermediate compound that is not isolated and that is treated with a basic aqueous medium. By means of this process, the derivatives are obtained more quickly and more economically.

PREPARATION OF 1-(BENZYLOXYCARBONYL)HEXAHYDRO-3-PYRIDAZINE CARBOXYLIC ACID, A PROTECTED PIPERAZIC ACID

A preparation of 1-(benzyloxycarbonyl)hexahydro-3-pyridazinecarboxylic acid in five steps (73percent overall yield) from 4-phenylurazole is described.