72121-22-3

Upstream product

• 613-90-1 benzoyl cyanide 
• 69504-00-3 N⁶-Benzoyl-5'-O-(monomethoxytrityl)adenosine 
• 72121-21-2 N⁶,3'-O-dibenzoyladenosine 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 4546-55-8 N-benzoyladenosine 
• 1663-61-2 triethoxymethylbenzene 
• 98-88-4 benzoyl chloride 

Downstream Products

• 72121-23-4 6-N,3'-O-Dibenzoyl-5'-O-<(4-methoxyphenyl)diphenylmethyl>adenosin-2'-<(2-cyanethyl)(2,2,2-tribromethyl)phosphat> 
• 20187-82-0 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine 
• 113297-64-6 N⁶,O^3'-dibenzoyl-5'-O-(4-monomethoxytrityl)-2'-O-[2-(4-nitrophenylethyl)-phosphato]adenosine triethylammonium salt 
• 82083-21-4 6-N,3'-O-Dibenzoyladenosin-2'-<(2-cyanethyl)(2,2,2-tribromethyl)phosphat> 
• 308356-19-6 9-[2-deoxy-2-fluoro-5-O-(p-monomethoxy)trityl-β-D-arabinofuranosyl]-N⁶-benzoyladenine 

Relevant academic research and scientific papers

Role of the stereochemistry of 3'-fluoro-3'-deoxy analogues of 2-5A in binding to and activation of mouse RNase L

The synthesis of two sets of analogues of 2-5A trimer containing 9-(3-fluoro-3-deoxy-β-D-xylo-furanosyl)adenine (AF) or 3'-fluoro-3'-deoxyadenosine (AF) at different positions of the chain is described, along with the preparation of the corresponding 5'-monophosphates and 5'-diphosphorylated (core) trimers.The ability of each ribo and xylo isomeric pair of fluorodeoxy analogues of 2-5A (i) to compete with p3(A2'p)3A3'pC3'p for binding to RNase L in L929 cell extracts, and (ii) to activate the partially purified RNase L from L929 cell extracts to hydrolyze poly(U), was compared to that of the related 3'-deoxy analogue and the parent trimer, p3A3, using radiobinding and RNase L-(2',5')pentaadenylate(core)-agarose assays, respectively.Evidence is presented to show that the stereochemistry of the trimers plays an important role, specifically in the second process.The most striking observation is that, compared to 2-5A, p3A(AF)A was found to be nine times more effective an activator of RNase L, whereas isomeric p3A(AF)A is 30 times less effective.

Nucleotides XXIV; Preparative Synthesis of Trimeric (2'-5')Oligoadenylic Acid

A preparative synthesis of the 2'-5'-Oligoadenylate trimer 19 via the phosphotriester approach is described.Selectively benzoylated derivatives of adenosine were used as starting materials.

SYNTHESIS OF A MODIFIED 2',5'-ADENYLATE TRIMER WITH A 2',3'-DI-O-(CARBOXYETHYL)-ETHYLIDENE TERMINAL GROUP

The trimer of 2',5'-oligoadenylic acid with a (2-carboxyethyl)athylidene group (16) at the 2'-terminal adenosine moiety and its 3'-deoxyadenosine analog (17) have been synthesized by the phosphotriester method.

8-Quinolinesulfone(3-nitro-1,2,4-triazolide), a New Effective Condensing Agent in the Oligonucleotide Synthesis

The synthesis of the dinucleoside diphosphate 10 with 2',5'-linkage according to the phosphotriester method is described.Starting from the triester 7 we compared the condensation of 8 and 9 with several sulfonazolides. 8-Quinolinesulfone(3-nitro-1,2,4-tri