721395-22-8Relevant academic research and scientific papers
A fast assembly of pentacyclic benz[f]indolo[2,3-a]quinolizidine core by tandem intermolecular formal Aza-[3 + 3] cycloaddition/Pictet-Spengler cyclization: A formal synthesis of (±)-tangutorine
Luo, Shengjun,Zhao, Jingrui,Zhai, Hongbin
, p. 4548 - 4550 (2004)
We have described a concise construction of the pentacyclic benz[f]indolo [2,3-a] quinolizidine intermediate 3 (with an overall yield of 54% for three steps), featuring a tandem intermolecular formal aza-[3 + 3] cycloaddition/Pictet-Spengler cyclization. The present work can be considered as a formal synthesis of β-carboline alkaloid (±)-tangutorine. Our strategy disclosed herein constitutes a new effective general synthetic approach toward the indoloquinolizidine family of alkaloids.
