721409-05-8Relevant academic research and scientific papers
Synthesis and biological evaluation of novel synthetic chalcone derivatives as anti-tumor agents targeting Cat L and Cat K
Wang, Yali,Xue, Situ,Li, Ruolan,Zheng, Zhihui,Yi, Hong,Li, Zhuorong
, p. 8 - 16 (2017/12/26)
A series of chalcone derivatives bearing benzamide or benzenesulfonamide moieties were synthesized and evaluated for their anti-tumor effect on HCT116, MCF7 and 143B cell lines in vitro. SAR analysis showed that compounds bearing a benzenesulfonamide grou
1-[M-CARBOXAMIDO(HETERO)ARYL-METHYL]-HETEROCYCLYL-CARBOXAMIDE DERIVATIVES
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, (2014/01/09)
The present invention relates to 1-[m-carboxamido(hetero)aryl-methyl]-heterocycyl- carboxamide compounds of formula (I) wherein X, Ar1, R1, R2, R3, R4, R5a, R5b and p are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.
1-[M-CARBOXAMIDO(HETERO)ARYL-METHYL]-PIPERIDINE-4-CARBOXAMIDE DERIVATIVES
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, (2014/02/15)
The present invention relates to 1-[m-Carboxamido(hetero)aryl-methyl]-piperidine-4-carboxamide derivatives of formula (I) wherein X, Ar1, R1, R2, R3, R4, R5 and p are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.
1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them
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Page/Page column 28, (2010/11/25)
1,4-Dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them. The outstanding invention is about substituted dihydropyridine-fused heterocycles useful for the treatment of cancer disease, especially for prev
