72141-57-2 Usage
Uses
Used in Pharmaceutical Industry:
Losulazine is used as an antihypertensive agent for the treatment of high blood pressure. Its mechanism of action involves the inhibition of norepinephrine reuptake, which results in a reduction of blood pressure and provides relief from hypertension-related symptoms.
Used in the Preparation of 7-(Trifluoromethyl)-4-aminoquinoline Hypotensives:
Losulazine is utilized in the synthesis of 7-(Trifluoromethyl)-4-aminoquinoline derivatives, which are also hypotensive agents. These novel compounds exhibit peripheral sympatholytic activity, making them potential candidates for the development of new antihypertensive medications.
Check Digit Verification of cas no
The CAS Registry Mumber 72141-57-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,1,4 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 72141-57:
(7*7)+(6*2)+(5*1)+(4*4)+(3*1)+(2*5)+(1*7)=102
102 % 10 = 2
So 72141-57-2 is a valid CAS Registry Number.
InChI:InChI=1/C27H22F4N4O3S/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25/h1-12,17H,13-16H2,(H,32,33)
72141-57-2Relevant academic research and scientific papers
7-(Triflluoromethyl)-4-aminoquinoline Hypotensives: Novel Peripheral Sympatholytics
McCall, John M.,TenBrink, R. E.,Kamdar, Bharat V.,Skaletzky, Louis L.,Perricone, Salvatore C.,et al.
, p. 133 - 137 (2007/10/02)
A family of 7-(trifluoromethyl)-4-aminoquinolines that are hypotensive agents and that act by a novel sympatholytic mechanism is described.Structure-activity relationships in this series have been elucidated.Some of the more potent hypotensives were evalu
Antihypertensive 4-aminoquinolines
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, (2008/06/13)
Antihypertensive compounds of the formula ll STR1 wherein X is chloro or trifluoromethyl; wherein R is an aromatic heterocyclic radical selected from the group consisting of triazinyl, pyrazinyl, pyridinyl, pyrimidinyl or the above radicals substituted by
