72141-57-2 Usage
Uses
Losulazine is used in the preparation of 7-?(Trifluoromethyl)?-?4-?aminoquinoline hypotensives: novel peripheral sympatholytics.
Check Digit Verification of cas no
The CAS Registry Mumber 72141-57-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,1,4 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 72141-57:
(7*7)+(6*2)+(5*1)+(4*4)+(3*1)+(2*5)+(1*7)=102
102 % 10 = 2
So 72141-57-2 is a valid CAS Registry Number.
InChI:InChI=1/C27H22F4N4O3S/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25/h1-12,17H,13-16H2,(H,32,33)
72141-57-2Relevant articles and documents
7-(Triflluoromethyl)-4-aminoquinoline Hypotensives: Novel Peripheral Sympatholytics
McCall, John M.,TenBrink, R. E.,Kamdar, Bharat V.,Skaletzky, Louis L.,Perricone, Salvatore C.,et al.
, p. 133 - 137 (2007/10/02)
A family of 7-(trifluoromethyl)-4-aminoquinolines that are hypotensive agents and that act by a novel sympatholytic mechanism is described.Structure-activity relationships in this series have been elucidated.Some of the more potent hypotensives were evalu