721445-64-3Relevant academic research and scientific papers
New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs
Almansa, Carmen,Bartrolí, Javier,Belloc, Jordi,Cavalcanti, Fernando L.,Ferrando, Rosa,Gómez, Luis A.,Ramis, Isabel,Carceller, Elena,Merlos, Manuel,García-Rafanell, Julián
, p. 5579 - 5582 (2007/10/03)
The synthesis and pharmacological evaluation of new water-soluble phosphoramidate derivatives of the COX-2 selective inhibitor cimicoxib (4) are described. The sulfonylphosphoramidic acid derivative 10 was converted to 4 in human plasma and showed excelle
NEW PHOSPHORAMIDE DERIVATIVES
-
Page 32-33, (2008/06/13)
New phosphoramide derivatives of formula (I) and the salts and solvates thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful as antiinflammatory and analgesic agents.
