72150-22-2

Usage

Uses

Used in Pharmaceutical Synthesis:
4,7-epoxy-3a,4,7,7a-tetrahydroisobenzofuran-1(3h)-one is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure and reactivity contribute to the development of new drugs and therapeutic agents.
Used in Organic Chemistry Research:
Due to its potential applications in the field of organic chemistry and chemical synthesis, 4,7-epoxy-3a,4,7,7a-tetrahydroisobenzofuran-1(3h)-one is utilized as a subject of study for understanding its properties and reactivity. This research can lead to the discovery of new reactions and applications in organic synthesis.
Used in Chemical Synthesis Industry:
In the chemical synthesis industry, 4,7-epoxy-3a,4,7,7a-tetrahydroisobenzofuran-1(3h)-one is used as a key component in the production of specific organic compounds. Its presence in the synthesis process can enhance the yield and efficiency of the desired products.

InChI:InChI=1/C8H8O3/c9-8-7-4(3-10-8)5-1-2-6(7)11-5/h1-2,4-7H,3H2

Upstream product

• 51112-81-3 endo, cis-7-oxabicyclo<2.2.1>hept-5-ene-2,3-dicarboxylic acid 
• 6766-44-5 7-oxabicyclo<2.2.1>heptene-exo-2,3-dicarboxylic anhydride 
• 6118-51-0 exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride 

Downstream Products

• 135440-55-0 6-exo-(3,5-dinitrobenzoyloxymethyl)-5-exo-vinyl-7-oxabicyclo<2.2.1>hept-2-ene 
• 135440-53-8 2-(Diphenyl-phosphinoyl)-1-((1R,2R,3S,4S)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl)-ethanol 
• 119119-26-5 tert-Butyl-diphenyl-(1-{(E)-2-[(1R,2S,3S,4S)-3-(tetrahydro-pyran-2-yloxymethyl)-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl]-vinyl}-hexyloxy)-silane 
• 119119-16-3 tert-Butyl-diphenyl-{(1R,2R,3R,4S)-3-[(E)-3-(tetrahydro-pyran-2-yloxy)-propenyl]-7-oxa-bicyclo[2.2.1]hept-5-en-2-ylmethoxy}-silane 
• 135440-52-7 5-exo-(2'-diphenylphosphinoyl-1'-oxoethyl)-6-exo-hydroxymethyl-7-oxabicyclo<2.2.1>hept-2-ene hemiacetal 
• 109685-75-8 (1S,2S,6S,7R,8S,9S)-8-Chloro-9-phenylsulfanyl-4,10-dioxa-tricyclo[5.2.1.0^2,6]decan-3-one 
• 109685-74-7 (1R,2R,6R,7S,8S,9S)-9-Chloro-8-phenylsulfanyl-4,10-dioxa-tricyclo[5.2.1.0^2,6]decan-3-one 
• 109685-77-0 (1R,2R,6R,7S,8R,9R)-8-Chloro-9-(2-nitro-phenylsulfanyl)-4,10-dioxa-tricyclo[5.2.1.0^2,6]decan-3-one 
• 109685-76-9 (1R,2R,6R,7S,8S,9S)-9-Chloro-8-(2-nitro-phenylsulfanyl)-4,10-dioxa-tricyclo[5.2.1.0^2,6]decan-3-one 
• 6253-21-0 3α-hydroxymethyl-7α-oxabicyclo[2.2.1]heptane-2α-carboxylic acid lactone 
• 109685-79-2 (1S,2S,6S,7R,8S,9S)-8-Chloro-9-(2,4-dinitro-phenylsulfanyl)-4,10-dioxa-tricyclo[5.2.1.0^2,6]decan-3-one 
• 109685-78-1 (1R,2R,6R,7S,8S,9S)-9-Chloro-8-(2,4-dinitro-phenylsulfanyl)-4,10-dioxa-tricyclo[5.2.1.0^2,6]decan-3-one 
• 109685-81-6 (1S,2S,6S,7R,8S,9S)-8-Chloro-9-phenylselanyl-4,10-dioxa-tricyclo[5.2.1.0^2,6]decan-3-one 
• 109685-80-5 (1R,2R,6R,7S,8S,9S)-9-Chloro-8-phenylselanyl-4,10-dioxa-tricyclo[5.2.1.0^2,6]decan-3-one 

Relevant academic research and scientific papers

Metal hydride reductions of unsymmetrically substituted cyclic anhydrides attached to strained ring systems

A dramatic reversal in regioselectivity is observed in the metal hydride reduction of unsimmetrical cyclic anhydrides such as 2, 3, and 4 compared to cyclic anhydrides attached to bridged ring systems (e.g.1).The synthesis of model cyclic anhydrides attached to strained rings is described and the ratios of isomeric lactones obtained upon reduction with metal hydride are reported.On the basis of theoretical calculations and, taking into account the intrinsic reactivity of the carbonyl group, the antiperiplanar effect, and steric congestion, an explanation is offered for the regioselectivity observed in the reduction of these compounds.

Synthesis of thromboxane A2 analogue (+/-)-(9,11),(11,12)-dideoxa-(9,11a)-oxa thromboxane A2

A synthesis of the thromboxane A2 analogue, (+/-)-(9,11),(11,12)-dideoxa-(9,11a)-oxa-thromboxane A2 (TXA2) starting from the exo-adduct 3 of maleic anhydride and furan is described

A SIMPLE SYNTHESIS OF BICYCLOHEPTANE SYSTEM,A KEY POTENTIAL INTERMEDIATE FOR STABLE PROSTAGLANDIN H2 ANALOGUE

A simple and efficient synthesis of 6-cyanomethyl-1-methoxycarbonylbicycloheptane system leading to stable prostaglandin H2 analogue is described.