72153-49-2Relevant academic research and scientific papers
Supramolecular Host-Selective Activation of Iodoarenes by Encapsulated Organometallics
Bender, Trandon A.,Morimoto, Mariko,Bergman, Robert G.,Raymond, Kenneth N.,Toste, F. Dean
supporting information, p. 1701 - 1706 (2019/04/11)
Supramolecular hosts offer defined microenvironments that facilitate selective host-guest interactions, enabling reactivity that would otherwise be challenging in bulk solution. While impressive rate enhancements and selectivities have been reported, similar reactivity can often be accessed through modifications of reaction conditions even in the absence of the host. We report here an oxidative addition of aryl halides across the metal centers in Cu(I) and Pd(II) organometallics that is assisted by the presence of a supramolecular host, realized via electrostatic stabilization and increased local substrate concentrations. When reaction conditions were screened to assess background reactivity, alternative reactivity (typically decomposition) resulted, indicating that encapsulation led to host-selective reaction trajectories.
Preparation and (31)P nuclear magnetic resonance studies of chiral phosphines
Payne, Nicholas C.,Stephan, Douglas W.
, p. 15 - 21 (2007/10/02)
The reaction of Li metal with alkyldiphenylphosphines generates the alkylphenylphosphide anions, which can undergo subsequent reactions with alkyl halides to give chiral phosphines (RR'R''P).The (31)P nmr chemical shifts have been measured for these phosphines, and show greater deviations from the values predicted by the first order additivity model than do those of more symmetrical phosphines (i.e., R3P and R2R'P).The shifts for these chiral molecules, and for a wide range of other phosphines, can be accurately predicted using a second order pairwise additivity scheme.The dependence of the observed and calculated chemical shifts upon electronegativity and steric factors is discussed.
