72156-60-6Relevant academic research and scientific papers
Solvent-free peptide synthesis assisted by microwave irradiation: Environmentally benign synthesis of bioactive peptides
Mahindra, Amit,Patel, Neha,Bagra, Nitin,Jain, Rahul
, p. 3065 - 3069 (2014/01/06)
An efficient and facile, solvent-free peptide synthesis assisted by microwave irradiation, using DIC/HONB as the coupling reagent combination is reported. Key features of this original protocol are solvent-free synthesis, very short reaction time and scal
Microwave-assisted solution phase peptide synthesis in neat water
Mahindra, Amit,Nooney, Karthik,Uraon, Shrikant,Sharma, Krishna K.,Jain, Rahul
, p. 16810 - 16816 (2013/09/23)
An environmentally benign protocol for solution phase peptide synthesis has been developed in neat water using TBTU/HOBt/DIEA as a coupling combination under microwave irradiation. Key features of this procedure are the replacement of commonly used toxic organic solvents like DMF and NMP, the use of lower amounts of reactants, compatibility with both N-α-Boc- and N-α-Fmoc-protected amino acids and all commonly used side-chain protective groups, short reaction time, and racemization-free synthesis in high yield and purity. The Royal Society of Chemistry 2013.
Histone deacetylase inhibitors: Synthesis of cyclic tetrapeptides and their triazole analogs
Singh, Erinprit K.,Nazarova, Lidia A.,Lapera, Stephanie A.,Alexander, Leslie D.,McAlpine, Shelli R.
supporting information; experimental part, p. 4357 - 4360 (2010/09/12)
Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives is described. HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated. The biological data demonstrate that incorporation of a triazole unit improves the HDAC inhibitory activity.
Copper-catalyzed cyclization of lodo-tryptophans: A straightforward synthesis of pyrroloindoles
Coste, Alexis,Toumi, Mathieu,Wright, Karen,Razafimahaleo, Vanessa,Couty, Francois,Marrot, Jerome,Evano, Gwilherm
supporting information; experimental part, p. 3841 - 3844 (2009/07/01)
(Chemical Equation Presented) Pyrroloindoles are a key structural motif found in a wide number of biologically active alkaloids. Intramolecular copper-catalyzed coupling of readily accessible 2-iodo-tryptophan derivatives occurs in excellent yield, afford
Selective inhibitors of the serine protease plasmin: Probing the S3 and S3′ subsites using a combinatorial library
Xue, Fengtian,Seto, Christopher T.
, p. 6908 - 6917 (2007/10/03)
A combinatorial library of 400 serine protease inhibitors with the general structure Cbz-Xaa-Trp-cyclohexanone-Trp-Yaa-OH has been constructed. The library was synthesized on the solid phase using mix-and-split synthesis, where 20 di
Synthesis of endothiopeptides and their cyclization to 1,3-thiazol- 5(4H)-imines
Lehmann, Juerg,Heimgartner, Heinz
, p. 1899 - 1915 (2007/10/03)
Further investigations of the synthesis of endothio analogues of the segment 1-10 (8) of an apolar analogon of zervamicin IIA are described. The endothiodecapeptide Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Ψ(CS)-Pro-OMe (10) has been prepared in good yield
