2577-46-0

Basic information

• Product Name: Methyl L-isoleucinate
• Synonyms: methyl L-isoleucinate;(3S)-3-Methyl-L-norvaline methyl ester;(3S)-L-Isoleucine methyl ester;L-Isoleucine methyl;(2S,3S)-methyl 2-amino-3methylpentanoate;(2S,3S)-2-Amino-3-methylpentanoic acid methyl ester
• CAS NO: 2577-46-0
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• EINECS: 219-931-0
• Mol File: 2577-46-0.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 169.203 °C at 760 mmHg
• Flash Point: 42.685 °C
• Appearance: /
• Density: 0.955 g/cm³
• Vapor Pressure: 1.56mmHg at 25°C
• Refractive Index: 1.435
• Storage Temp.: 2-8°C
• PKA: 7.98±0.39(Predicted)
• CAS DataBase Reference: Methyl L-isoleucinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl L-isoleucinate(2577-46-0)
• EPA Substance Registry System: Methyl L-isoleucinate(2577-46-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2577-46-0(Hazardous Substances Data)

Usage

Uses

(2S,3S)-Methyl 2-Amino-3-methylpentanoate is used in preparation method of polybutylene succinate.

InChI:InChI=1/C7H15NO2/c1-4-5(2)6(8)7(9)10-3/h5-6H,4,8H2,1-3H3

Upstream product

• 67-56-1 methanol 
• 319-78-8 D-Isoleucine 
• 1356449-88-1 calyxamide B 
• 73-32-5 L-isoleucine 
• 1169571-12-3 aspereline A 
• 1169571-13-4 aspereline B 
• 1169571-14-5 aspereline C 
• 1169571-16-7 aspereline E 
• 1169571-17-8 aspereline F 
• 1356449-87-0 calyxamide A 
• 73-32-5 DL-isoleucine 
• 319-78-8 isoleucine 
• 1509-34-8 D-allo-isoleucine 
• 60667-85-8 D-allo-isoleucine methyl ester hydrochloride 

Downstream Products

• 78569-25-2 Z-L-Leu-D-Ileu-OH 
• 20807-11-8 ((benzyloxy)carbonyl)glycyl-L-isoleucine 
• 27482-73-1 ZTyrIleOMe 
• 5254-68-2 N-(N,O-bis-benzyloxycarbonyl-L-tyrosyl)-L-isoleucine methyl ester 
• 122242-36-8 S-benzyl-N-benzyloxycarbonyl-L-cysteinyl=>L-phenylalanyl=>L-isoleucine methyl ester 
• 86961-90-2 S-benzyl-N-benzyloxycarbonyl-cysteinyl=>tyrosyl=>isoleucine methyl ester 
• 102320-12-7 N-(O-acetyl-N-formyl-L-tyrosyl)-L-isoleucine methyl ester 
• 42537-96-2 N-(N-benzyloxycarbonyl-L-leucyl)-L-isoleucine 
• 121467-96-7 S-benzyl-N-(toluene-4-sulfonyl)-cysteinyl=>tyrosyl=>isoleucine methyl ester 
• 14445-54-6 L-isoleucinamide 
• 1948-78-3 DL-isoleucine hydroxyamide 
• 59189-00-3 N-carbobenzyloxy-L-tryptophanyl-L-isoleucine methyl ester 
• 40290-68-4 Z-Ala-Ile-OMe 
• 100076-44-6 2-[3-((S)-1-Methoxycarbonyl-2-methyl-butyl)-ureido]-benzoic acid methyl ester 

Relevant articles and documents

Synthesis and evaluation of antitumor activities of 4-selenopyrimidine derivatives

Pyrimidine antimetabolic agents are the essential drugs in treatment of various tumors. Novel synthesis and biological evaluation of the pyrimidine derivatives incorporating selenium element and amino acid carrier as potential antitumor agents have not been tried and studied. Based on the biological significance of pyrimidine structure, these two additional elemental fragments maybe enhance the antitumor effect and reduce toxic side effects of pyrimidine agents. The aim of this paper is to synthesis a series of 4-selenopyrimidine derivatives in order to find more potent lead compounds against cancer. In this study, 12 new 4-selenopyrimidine derivatives that are unstable in acidic solutions but very stable in alkaline and neutral solutions avoiding light were synthesized, and the antitumor activities on HepG2 cell lines of these compounds were evaluated by MTT assay. The results have shown that these compounds could reduce the proliferation of HepG2 cells in a dose-dependent fashion, and the inhibitory activity of compounds a6 was greater than that of positive control 5-fluorouracil (5-FU), the IC50 for a6 was 3.63 μM. In the comprehensive analysis of the structure–activity relationship, we could draw the antitumor effect of selenouracil derivatives is stronger than those of selenothymine derivatives. These results suggest that the substituent groups of selenium element and amino acid on the pyrimidine derivatives are vital for their antitumor activities on HepG2 cells.

Cleavable Amide Bond: Mechanistic Insight into Cleavable 4-Aminopyrazolyloxy Acetamide at Low pH

The cleavage of amide bonds under mild acidic conditions is a rare chemical event. N-Acetamide bond of peptides is extremely stable even under the strongest organic acid trifluoromethanesulfonic acid. This report mechanistically describes a new cleavable amide bond in 4-aminopyrazolyloxy acetamide peptide analogues under mild acidic conditions such as trifluoroacetic acid (10-20%) or HCl (0.1-4.0 N) at room temperature, and the formation of unusual lactam from 4-aminopyrazolyloxy acetic acid after evaporation of solvent. This is a rare chemical event in peptide bond, which could be explored as acid-sensitive protecting group of free amines.

Heterocyclic Compounds from the Mushroom Albatrellus confluens and Their Inhibitions against Lipopolysaccharides-Induced B Lymphocyte Cell Proliferation

Eight hetereocyclic compounds conflamides B-I with an unprecedented skeleton and their precursor conflamide A were isolated from the mushroom Albatrellus confluens. Their structures and absolute configurations were determined by use of NMR studies, total synthesis, and calculated ECD spectra. Conflamides D and E were found to exhibit potent inhibition against LPS-induced B lymphocyte cell proliferation with IC50 values 1.48 and 5.71 μM, respectively.