721880-65-5

Basic information

• Product Name: C₁₀H₁₂BrNO₂
• CAS NO: 721880-65-5
• Molecular Weight: 258.115
• Mol File: 721880-65-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₀H₁₂BrNO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₁₂BrNO₂(721880-65-5)
• EPA Substance Registry System: C₁₀H₁₂BrNO₂(721880-65-5)

Safety Data

• Hazardous Substances Data: 721880-65-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 82311-69-1 (S)-2-amino-3-(3-bromophenyl)propanoic acid 
• 546115-43-9 methyl (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate 
• 30163-20-3 2-amino-3-(3-bromophenyl)propanoic acid 
• 267225-27-4 (2R)-2-amino-3-(2-bromophenyl)propanoic acid 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.

Design of selective Cathepsin inhibitors

A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors.