721884-80-6

Basic information

• Product Name: trans-N-(3-hydroxycyclohexyl)benzamide
• CAS NO: 721884-80-6
• Molecular Formula: C13H17NO2
• Molecular Weight: 219
• Mol File: 721884-80-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: trans-N-(3-hydroxycyclohexyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: trans-N-(3-hydroxycyclohexyl)benzamide(721884-80-6)
• EPA Substance Registry System: trans-N-(3-hydroxycyclohexyl)benzamide(721884-80-6)

Safety Data

• Hazardous Substances Data: 721884-80-6(Hazardous Substances Data)

Upstream product

• 6850-39-1 3-aminocyclohexanol 
• 98-88-4 benzoyl chloride 
• 6850-39-1 (+/-)-cis-3-aminocyclohexanol 
• 177366-86-8 N-<1-(Trimethylsiloxy)hex-5-enyl>formamide 
• 764-59-0 hex-5-en-1-al 
• 102653-17-8 (+/-)-trans-1-acetoxy-3-acetylamino-cyclohexane 
• 13941-94-1 (rac)-trans-1-(3-hydroxycyclohexyl)benzamide 

Downstream Products

• 112948-62-6 (+/-)-trans-1-benzoylamino-3-(toluene-4-sulfonyloxy)-cyclohexane 
• 102653-17-8 (+/-)-trans-1-acetoxy-3-acetylamino-cyclohexane 
• 57376-99-5 (+/-)-N-(trans-3-hydroxy-cyclohexyl)-acetamide 

Relevant articles and documents

Resolution of trans-3-aminocyclohexanol

(R,R)- and (S,S)-trans-3-Aminocyclohexanol were prepared via an enzymatic resolution of (±)-trans-1-acetoxy-3-benzylamido-cyclohexane with >95% enantiomeric excess.

Reactions of 1-acylamino-1-(trimethylsiloxy)alkanes: Versatile precursors to acylimines

1-Acylamino-1-(trimethylsiloxy)alkanes react with carbon and heteroatom nucleophiles to give the corresponding 1-substituted-1-acylaminoalkanes. The 1-acylamino-1-(trimethylsiloxy)alkanes can also give rise to enamides, and by this route the mild antibiotic tuberin, and the isomeric (Z)-tuberin have been prepared. A further example of their reactions is illustrated with the acid-catalysed intramolecular cyclisation onto a carbon-carbon double bond. These transformations show that 1-acylamino-1-(trimethylsiloxy)alkanes are versatile precursors to synthetically useful acylimines.