72189-44-7

Basic information

• Product Name: C₉H₁₀O₅
• CAS NO: 72189-44-7
• Molecular Weight: 198.175
• Mol File: 72189-44-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: >196°C (dec.)
• CAS DataBase Reference: C₉H₁₀O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₉H₁₀O₅(72189-44-7)
• EPA Substance Registry System: C₉H₁₀O₅(72189-44-7)

Safety Data

• Hazardous Substances Data: 72189-44-7(Hazardous Substances Data)

Usage

Uses

Salbutamol Glyoxal Impurity that is synthesized from C369215 (3-Chloromethyl-4-hydroxyacetophenone).

Upstream product

• 90-01-7 salicylic alcohol 
• 298-12-4 Glyoxilic acid 
• 50-00-0 formaldehyd 
• 1198-84-1 4-hydroxymandelic acid 

Relevant articles and documents

Method for preparing Vilanterol

The invention discloses a method for preparing Vilanterol, and belongs to the field of drug synthesis. The method includes the steps: (1) performing addition reaction on salicyloyl and glyoxylic acidto generate an intermediate 1; (2) performing chiral resolution on the intermediate 1 to obtain a chiral intermediate 2; (3) performing acylation reaction on the intermediate 2 and an intermediate 3 to generate an intermediate 4; (4) reducing the intermediate 4 to obtain the Vilanterol. The intermediate 3 is obtained by performing Darebin reaction on an intermediate 5. Raw materials are easily obtained, a synthetic route is short, production cost is reduced, reaction conditions are mild, and the method is simple in operation and suitable for industrial production.

Preparation method of vilanterol intermediate

The invention discloses a preparation method of a vilanterol intermediate and belongs to the field of drug synthesis. The method is characterized in that 4-hydroxy-mandelic acid is taken as a raw material and is subjected to formylation reaction to obtain