1198-84-1Relevant articles and documents
Synthesis of racemic mandelic acids with the composite phase transfer catalyst β-cyclodextrin-[bmim]PF6
Yang, Ben-Yong,Yang, De-Hong
, p. 484 - 485 (2011)
Ionic liquids were employed as a part of composite phase transfer catalyst to synthesise mandelic acid, and it is found that [bmim]PF6 coupled with β-cyclodextrin is the most effective catalyst, which was also applicable to other reactions used to synthesise mandelic acid derivatives. Reaction conditions were optimized and the products were characterised by 1H NMR and IR.
Metal ion catalysis in the hydroxyalkylation of phenol with glyoxylic acid
Hoefnagel, A. J.,Peters, J. A.,Bekkum, H. van
, p. 242 - 247 (1988)
The hydroxyalkylation reaction of phenol with glyoxylic acid in aqueous medium is found to be homogeneously catalyzed by various metal ions.Catalysis with MII ions results in a reaction product with an ortho/para ratio of 0.2 to 1.1, whereas catalysis using higher valent cations, because of their ability to form mixed complexes with phenol and glyoxylic acid, affords a reaction product with an ortho/para ratio 1.3 to 28.The catalyzed Cannizzaro reaction of glyoxylic acid was observed as a side-reaction.Addition of a suitable inert ligand, e. g. oxalic acid or NTA, is shown to decrease the ortho/para ratio and suppress the Cannizzaro reaction.The coordination of glyoxylic acid and its hydrate with several cations has been studied by NMR techniques and a mechanism of the catalyzed hydroxyalkylation and Cannizzaro reaction is proposed.
Butenolide derivative as well as preparation method and application thereof
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Paragraph 0045-0048, (2020/07/21)
The invention discloses a butenolide compound as well as a preparation method and an application thereof. The butenolide derivative has the inhibitory activity of protein tyrosine phosphatase 1B (PTP1B), improves insulin resistance of HepG2 cells, generates a remarkable hypoglycemic effect and can be used for preparing a medicine for treating diabetes mellitus.
Method for producing optionally substituted aliphatic, aromatic or heteroaromatic aldehydes
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, (2008/06/13)
The invention relates to a method for producing optionally substituted aliphatic, aromatic or heteraromatic aldehydes of formula (I), whereby the R represents a C1-C20 Alkyl radical, an aromatic or heteraromatic radical Ar which can optionally be substituted once or on a number of occasions by OH, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 carboxylic acids or ester containing 1-6 C atoms in the ester part, phenyl, halogen, SO3H, NO2, NR1R2 or SR1 whereby R1 and R2 can be independently H, phenyl or C1-C6 alkyl. The invention is characterised by a compound of formula (II) wherein R has the above meaning, a) is diazotized in an acidic medium, at a temperature of between ?10 ?+100 ° C. by a diazoation reagent and is transformed into the corresponding hydroxy carboxy acid whereby b) is transformed, by means of oxygen, into the appropriate aldehyde of formula (I) in the presence of a metal, the salt thereof, oxide or hydroxide as a catalyst.
