721923-23-5Relevant academic research and scientific papers
Sodium borohydride/methoxydiethylborane mediated syn-1,3-stereoselective total synthesis of herbarumin-III
Yadav,Narasimhulu,Vikram Reddy,Subba Reddy,Al Khazim Al Ghamdi, Ahmad
experimental part, p. 1075 - 1082 (2011/10/02)
A simple and efficient stereoselective total synthesis of 10-membered macrolide, herbarumin-III is described. The key steps involved in this synthesis are the selective terminal alkylation of ethyl acetoacetate with ethyl bromide, Sharpless epoxidation, NaBH4/Et2BOMe mediated stereoselective syn-1,3-asymmetric reduction, esterification and olefin metathesis.
A concise stereoselective total synthesis of herbarumin III
Yadav, Jhillu S.,Kumar, Veerjala Naveen,Rao, Ramisetti Srinivasa,Srihari, Pabbaraja
experimental part, p. 1938 - 1942 (2009/04/04)
A stereoselective total Synthesis of the phytotoxic compound herbarumin III has been achieved by utilizing Crimmins's aldol approach, 1,3-syn asymmetric reduction, and an olefin metathesis reaction as the key steps.
First total synthesis of herbarumin III
Gurjar, Mukund K.,Karmakar, Sukhen,Mohapatra, Debendra K.
, p. 4525 - 4526 (2007/10/03)
An asymmetric 10-step total synthesis of herbarumin III in 24% overall yield is described using ring-closing metathesis as the key step.
