721959-05-3Relevant academic research and scientific papers
New analogues of the potent cytotoxic saponin OSW-1
Wojtkielewicz, Agnieszka,D?ugosz, Maciej,Maj, Jadwiga,Morzycki, Jacek W.,Nowakowski, Micha?,Renkiewicz, Joanna,Strnad, Miroslav,Swaczynová, Jana,Wilczewska, Agnieszka Z.,Wójcik, Jacek
, p. 3667 - 3673 (2008/02/09)
Saponin OSW-1 (5e-G2; 3β,16β,17α-trihydroxycholest-5-en-22- one 16-O-{O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-(1→3)-2-O- acetyl-α-arabinopyranoside}) analogues: with modified side chain (5a/d-G2), 22-deoxo-23,24,25,26,27-pentanor- (14), 22-deoxo-23-o
Synthesis of analogues of a potent antitumor saponin OSW-1
Morzycki, Jacek W.,Wojtkielewicz, Agnieszka,Wolczynski, Slawomir
, p. 3323 - 3326 (2007/10/03)
A series of side chain analogues (5a-e), a 22-glycosylated isomer (10), and 16β-O-L-arabinosyl (13a) or 16β-O-D-xylosyl (13b) analogues of OSW-1 were synthesized. All analogues were found to be less cytotoxic against breast and endometrial cancer cell lines than the natural product.
