72198-11-9Relevant academic research and scientific papers
Studies directed towards nonyl acridine orange analogues having the potential to act as FRET donors with the PDT drug Pc 4
Zhang, Ping,Yang, Yang,Liu, Yun,Rodriguez, Myriam E.,Kenney, Malcolm E.
, p. 29391 - 29403 (2018/06/04)
A group of nonyl acridine orange analogues (NAO) was prepared which were designed to have the potential of possessing visible bands allowing them to act in cells as fluorescence resonance energy transfer (FRET) donors with the photodynamic therapy drug Pc 4. The existence of Pc 4-FRET with the analogues of NAO in MCF-7c3 cells was probed. The results suggest that NAO analogues giving strong FRET with Pc 4 in cells can be found.
Isoindol-1,3-dione and isoindol-1-one derivatives with high binding affinity to β-amyloid fibrils
Lee, Hyu Ji,Lim, Soo Jeong,Oh, Seung Jun,Moon, Dae Hyuk,Kim, Dong Jin,Tae, Jinsung,Yoo, Kyung Ho
, p. 1628 - 1631 (2008/09/19)
Based on the structural features of Indoprofen and PIB, a series of isoindol-1,3-diones 1a-k and isoindol-1-ones 2a-l were designed and synthesized. These 23 compounds were evaluated by competitive binding assay against aggregated Aβ42 fibrils using [125I]TZDM. All the isoindolone derivatives showed very good binding affinities with Ki values in the subnanomolar range (0.42-0.94 nM). Among them, isoindol-1,3-diones 1i and 1k and isoindol-1-ones 2c and 2i exhibited excellent binding affinities (Ki = 0.42-0.44 and 0.46-0.49 nM) than those of Indoprofen (Ki = 0.52 nM) and PIB (Ki = 0.70 nM). These results suggest that isoindolones could be served as a scaffold for potential AD diagnostic probes to monitor Aβ fibrils.
