72198-15-3Relevant academic research and scientific papers
Synthesis of mandelic acid derived phthalimides as a new class of antiinflammatory and antimicrobial agents
Varala, Ravi,Kotra, Vijay,Alam, M. Mujahid,Kumar, N. Ramesh,Ganapaty,Adapa, Srinivas R.
, p. 1243 - 1248 (2008/12/23)
In the present study, a new series of 2-(1,3-dioxo-2,3-dihydro-1H-2- isoindolyl) ethyl 2-hydroxy-2-(substituted phenyl) acetates 6a-e have been synthesized from the combination of N-(2-hydroxy ethyl) phthalimide 5 and substituted mandelic acids 2a-e which resulted in both anti-inflammatory and antimicrobial activity. These compounds have been characterized by IR, 1H NMR, mass spectral and elemental analysis. Among the compounds tested for anti-inflammatory activity, compound 6b and 6c showed significant activity and compound 6d showed potent antibacterial and antifungal activity. The anti-inflammatory activity has been determined by carrageenan induced acute paw oedema in rats. The results are discussed in the text. The in vitro antibacterial and antifungal activity of the compounds have been evaluated by paper disc diffusion method. The minimum inhibitory concentrations (MIC) of the compounds have also been determined by agar streak dilution method.
Synthesis and Properties of Optically Active Phenoxypropionates. Effect of Halogeno Substituent in the Core on Physical Properties
Sugita, Shin-Ichi,Toda, Susumu,Yoshiyasu, Takashi,Teraji, Tsutomu
, p. 399 - 406 (2007/10/02)
Chiral phenoxypropionates having halogenated 2,5-diphenylpyrimidine cores were synthesized and the effect of a halogeno-substituent on the physical properties such as mesomorphic behavior, spontaneous polarization (Ps) and response time (τ) were investigated.The introduction of a halogen atom to the phenyl ring of 2,5-diphenylpyrimidine core led to a decrease in the thermal stability of mesophases.The Ps values in the achiral host liquid crystal mixture were increased by introducing the halogen atom.However, response times were not improved. - Keywords: ferroelectric liquid crystal, phenoxypropionate, halogeno-substituent
